Technology Process of (4-Bromo-2-hydroxyphenyl)(phenyl)methanone
There total 5 articles about (4-Bromo-2-hydroxyphenyl)(phenyl)methanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
phenylmagnesium bromide; 4-bromo-2-hydroxy-benzonitrile;
In
tetrahydrofuran;
at 0 - 65 ℃;
for 5h;
Schlenk technique;
Inert atmosphere;
With
hydrogenchloride; ethanol;
In
tetrahydrofuran;
at 80 ℃;
for 14.5h;
Schlenk technique;
Inert atmosphere;
DOI:10.1016/j.ejmech.2021.113930
- Guidance literature:
-
With
dipotassium hydrogenphosphate; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; triphenylphosphine;
In
tetrahydrofuran;
at 25 ℃;
for 8h;
Schlenk technique;
Inert atmosphere;
Sealed tube;
Irradiation;
DOI:10.1002/chem.201903816
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium hydroxide / water / 20 °C
2: [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; dipotassium hydrogenphosphate; triphenylphosphine / tetrahydrofuran / 8 h / 25 °C / Schlenk technique; Inert atmosphere; Sealed tube; Irradiation
With
dipotassium hydrogenphosphate; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; triphenylphosphine; sodium hydroxide;
In
tetrahydrofuran; water;
DOI:10.1002/chem.201903816
