Acetamide, 2-[(2,2-dimethoxyethyl)amino]-N-(2-phenylethyl)-

Base Information

• Chemical Name: Acetamide, 2-[(2,2-dimethoxyethyl)amino]-N-(2-phenylethyl)-
• CAS No.: 90142-14-6
• Molecular Formula: C14H22N2O3
• Molecular Weight: 266.34
• UNII: YCR5VA6YAP
• DSSTox Substance ID: DTXSID00448569
• Nikkaji Number: J982.170H
• Wikidata: Q82267623

Synonyms:90142-14-6;Acetamide, 2-[(2,2-dimethoxyethyl)amino]-N-(2-phenylethyl)-;2-[(2,2-dimethoxyethyl)amino]-N-(2-phenylethyl)acetamide;YCR5VA6YAP;2-((2,2-dimethoxyethyl)amino)-N-phenethylacetamide;SCHEMBL9935086;DTXSID00448569;KOMKLFDEPKFXBU-UHFFFAOYSA-N;1-(Phenethylamino)-2-[(2,2-dimethoxyethyl)amino]ethanone

Chemical Property of Acetamide, 2-[(2,2-dimethoxyethyl)amino]-N-(2-phenylethyl)-

Chemical Property:

• PSA: 63.08000
• LogP: 1.78500
• XLogP3: 1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 9
• Exact Mass: 266.16304257
• Heavy Atom Count: 19
• Complexity: 239

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(CNCC(=O)NCCC1=CC=CC=C1)OC

Technology Process of Acetamide, 2-[(2,2-dimethoxyethyl)amino]-N-(2-phenylethyl)-

There total 5 articles about Acetamide, 2-[(2,2-dimethoxyethyl)amino]-N-(2-phenylethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-chloro-N-phenethylacetamide (13156-95-1) + 2,2-dimethoxyethylamine (22483-09-6) → N-2-phenylethyl 2-N-(2,2-dimethoxyethylamino)acetamide hydrochloride (90142-14-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 - 75 ℃; for 5h; Large scale; Green chemistry;

DOI:10.14233/ajchem.2013.14931

Reference yield: 78.2%

chloroacetaldehyde dimethyl acetal (97-97-2) + glycinyl chloride hydrochloride (2184-96-5) + phenethylamine (64-04-0) → N-2-phenylethyl 2-N-(2,2-dimethoxyethylamino)acetamide hydrochloride (90142-14-6)

Guidance literature:

glycinyl chloride hydrochloride; phenethylamine; With triethylamine; In dichloromethane; at 0 - 10 ℃; for 1.5h; Industrial scale;

chloroacetaldehyde dimethyl acetal; In dichloromethane; for 2h; Solvent; Temperature; Reagent/catalyst; Reflux; Industrial scale;

Reference yield:

2-[(2,2-dimethoxyethyl)benzylamino]-N-phenethylacetamide (1380603-46-2) → N-2-phenylethyl 2-N-(2,2-dimethoxyethylamino)acetamide hydrochloride (90142-14-6)

Guidance literature:

With hydrogen; In methanol; at 25 - 67 ℃; for 20h; under 7500.75 Torr; Inert atmosphere; Large scale;

upstream raw materials:

2-chloro-N-phenethylacetamide

2,2-dimethoxyethylamine

2-[(2,2-dimethoxyethyl)benzylamino]-N-phenethylacetamide

phenethylamine

Downstream raw materials:

N-(2,2-dimethoxyethyl)-N-(2-oxo-2-(2-phenethylamino)-ethyl)cyclohexanecarboxamide

2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one

2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one

4-(cyclohexylcarbonyl)-3,4-dihydro-1-(2-phenylethyl)-2(1H)-pyrazinone

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