1-Chloro-2-(chloromethyl)-4-phenylbut-3-yn-2-ol

Base Information

Chemical Name:1-Chloro-2-(chloromethyl)-4-phenylbut-3-yn-2-ol
CAS No.:90160-64-8
Molecular Formula:C11H10Cl2O
Molecular Weight:229.106
Hs Code.:
DSSTox Substance ID:DTXSID20535086
Wikidata:Q82409187

Synonyms:1-Chloro-2-(chloromethyl)-4-phenylbut-3-yn-2-ol;90160-64-8;DTXSID20535086

Suppliers and Price of 1-Chloro-2-(chloromethyl)-4-phenylbut-3-yn-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Chloro-2-(chloromethyl)-4-phenylbut-3-yn-2-ol

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:4
Exact Mass:228.0108703
Heavy Atom Count:14
Complexity:228

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C#CC(CCl)(CCl)O

Technology Process of 1-Chloro-2-(chloromethyl)-4-phenylbut-3-yn-2-ol

There total 1 articles about 1-Chloro-2-(chloromethyl)-4-phenylbut-3-yn-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 534-07-6
1,3-Dichloroacetone

: 536-74-3
phenylacetylene

: 90160-64-8
1-chloro-2-(chloromethyl)-4-phenyl-3-butyn-2-ol

Guidance literature:: phenylacetylene; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h;

With cerium(III) chloride; In tetrahydrofuran; hexane; at -78 ℃; for 0.666667h;

1,3-Dichloroacetone; With cerium(III) chloride; In tetrahydrofuran; at -78 ℃; for 0.166667h;
DOI:10.1002/jccs.200300130

Reference yield: 90.0%

: 90160-64-8
1-chloro-2-(chloromethyl)-4-phenyl-3-butyn-2-ol

: 57951-69-6
2-methylene-4-phenylbut-3-yn-1-ol

Guidance literature:: With sodium hydroxide; tellurium; rongalite; In 1,4-dioxane; for 4h; Heating;
DOI:10.1016/S0040-4039(00)85270-3

Reference yield:

: 90160-64-8
1-chloro-2-(chloromethyl)-4-phenyl-3-butyn-2-ol

: 191479-41-1
3-chloromethyl-4-phenylbut-3-yne-1,2-diol

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / t-BuOK / 2-methyl-propan-2-ol / 20 °C

2: 90 percent / H₂SO₄ / acetonitrile / Heating

With sulfuric acid; potassium tert-butylate; In acetonitrile; tert-butyl alcohol;
DOI:10.1002/jccs.200300130