2-Methoxy-5-(Methoxycarbonyl)benzoic acid

Base Information

• Chemical Name: 2-Methoxy-5-(Methoxycarbonyl)benzoic acid
• CAS No.: 90183-43-0
• Molecular Formula: C10H10O5
• Molecular Weight: 210.186
• Hs Code.: 2918990090
• Mol file: 90183-43-0.mol

Synonyms:1,3-Benzenedicarboxylic acid,4-methoxy-,1-methyl ester;

Chemical Property of 2-Methoxy-5-(Methoxycarbonyl)benzoic acid

Chemical Property:

• Melting Point: 92-94 °C
• Boiling Point: 380.7±27.0 °C(Predicted)
• PKA: 3.72±0.10(Predicted)
• PSA: 72.83000
• Density: 1.282±0.06 g/cm3(Predicted)
• LogP: 1.18000

Purity/Quality:

2-Methoxy-5-(methoxycarbonyl)benzoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2-Methoxy-5-(Methoxycarbonyl)benzoic acid

There total 3 articles about 2-Methoxy-5-(Methoxycarbonyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

methyl 3-formyl-4-methoxybenzoate (145742-55-8) → 2-methoxy-5-(methoxycarbonyl)benzoic acid (90183-43-0)

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; at 20 ℃; for 1h;

DOI:10.1021/acs.jmedchem.7b01447

Reference yield:

methyl 4-hydroxylbenzoate (99-76-3,156291-94-0) → 2-methoxy-5-(methoxycarbonyl)benzoic acid (90183-43-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: magnesium chloride; triethylamine / 1,2-dichloro-ethane / 1 h / 40 °C

1.2: 3 h / 70 °C

2.1: potassium carbonate / acetone / 2 h / Reflux

3.1: sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium chlorite / tert-butyl alcohol; water / 1 h / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; potassium carbonate; triethylamine; magnesium chloride; In water; 1,2-dichloro-ethane; acetone; tert-butyl alcohol;

DOI:10.1021/acs.jmedchem.7b01447

Reference yield:

methyl 3-formyl-4-hydroxybenzoate (24589-99-9) → 2-methoxy-5-(methoxycarbonyl)benzoic acid (90183-43-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 2 h / Reflux

2: sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium chlorite / tert-butyl alcohol; water / 1 h / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; potassium carbonate; In water; acetone; tert-butyl alcohol;

DOI:10.1021/acs.jmedchem.7b01447

upstream raw materials:

methyl 3-formyl-4-methoxybenzoate

methyl 3-formyl-4-hydroxybenzoate

methyl 4-hydroxylbenzoate

Downstream raw materials:

methyl 3-{[(2,6-difluorophenyl)amino]carbonyl}-4-(methyloxy)benzoate

3-[(4-chlorophenyl)carbamoyl]-4-methoxybenzoic acid

4-Methoxy-3-(4-methoxy-phenylcarbamoyl)-benzoesaeure-methylester

4-methoxy-3-[(4-methoxyphenyl)carbamoyl]benzoic acid

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