4(1H)-Pyridinone, 2-[6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]hexyl]-2,3-dihydro-1-[(E)-[[(1S) -1-(methoxymethyl)-2-methylpropyl]imino]phenylmethyl]-, (2R)-

Base Information

Chemical Name:4(1H)-Pyridinone, 2-[6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]hexyl]-2,3-dihydro-1-[(E)-[[(1S) -1-(methoxymethyl)-2-methylpropyl]imino]phenylmethyl]-, (2R)-
CAS No.:904929-91-5
Molecular Formula:C30H50N2O3Si
Molecular Weight:514.824
Hs Code.:

4(1H)-Pyridinone,
2-[6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]hexyl]-2,3-dihydro-1-[(E)-[[(1S)
-1-(methoxymethyl)-2-methylpropyl]imino]phenylmethyl]-, (2R)-

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Chemical Property of 4(1H)-Pyridinone, 2-[6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]hexyl]-2,3-dihydro-1-[(E)-[[(1S) -1-(methoxymethyl)-2-methylpropyl]imino]phenylmethyl]-, (2R)-

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Technology Process of 4(1H)-Pyridinone, 2-[6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]hexyl]-2,3-dihydro-1-[(E)-[[(1S) -1-(methoxymethyl)-2-methylpropyl]imino]phenylmethyl]-, (2R)-

There total 3 articles about 4(1H)-Pyridinone, 2-[6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]hexyl]-2,3-dihydro-1-[(E)-[[(1S) -1-(methoxymethyl)-2-methylpropyl]imino]phenylmethyl]-, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: Trifluoro-methanesulfonate4-methoxy-1-{[(E)-(S)-1-methoxymethyl-2-methyl-propylimino]-phenyl-methyl}-pyridinium;

: 103483-32-5
1-iodo-6-(tert-butyldimethylsiloxy)hexane

: 904929-91-5
(2R)-2-(6-{(tert-butyl(dimethyl)silyl)oxy}heptyl)-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-2,3-dihydropyridin-4(1H)-one

Guidance literature:: 1-iodo-6-(tert-butyldimethylsiloxy)hexane; With tert.-butyl lithium; In diethyl ether; pentane; at -78 ℃; for 1h;

With magnesium bromide; In diethyl ether; pentane; at 20 ℃; for 1h;

Trifluoro-methanesulfonate4-methoxy-1-{[(E)-(S)-1-methoxymethyl-2-methyl-propylimino]-phenyl-methyl}-pyridinium;; In diethyl ether; dichloromethane; pentane; at -20 ℃;
DOI:10.1021/ol0609006

Reference yield:

: 620-08-6,1232006-56-2
4-methoxypyridine

: 904929-91-5
(2R)-2-(6-{(tert-butyl(dimethyl)silyl)oxy}heptyl)-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-2,3-dihydropyridin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: CH₂Cl₂ / -78 - 20 °C

2.1: tert-butyllithium / diethyl ether; pentane / 1 h / -78 °C

2.2: MgBr₂*Et₂O / diethyl ether; pentane / 1 h / 20 °C

2.3: 70 percent / diethyl ether; pentane; CH₂Cl₂ / -20 °C

With tert.-butyl lithium; In diethyl ether; dichloromethane; pentane;
DOI:10.1021/ol0609006

Reference yield:

: 87768-46-5
N-[(1S)-1-(methoxymethyl)-2-methylpropyl]benzamide

: 904929-91-5
(2R)-2-(6-{(tert-butyl(dimethyl)silyl)oxy}heptyl)-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-2,3-dihydropyridin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: CH₂Cl₂ / -78 - 20 °C

2.1: tert-butyllithium / diethyl ether; pentane / 1 h / -78 °C

2.2: MgBr₂*Et₂O / diethyl ether; pentane / 1 h / 20 °C

2.3: 70 percent / diethyl ether; pentane; CH₂Cl₂ / -20 °C

With tert.-butyl lithium; In diethyl ether; dichloromethane; pentane;
DOI:10.1021/ol0609006