3-Chloro-2,4,5,6-tetrafluoropyridine

Base Information

• Chemical Name: 3-Chloro-2,4,5,6-tetrafluoropyridine
• CAS No.: 1735-84-8
• Molecular Formula: C5ClF4N
• Molecular Weight: 185.508
• Hs Code.: 29333990
• Mol file: 1735-84-8.mol

Synonyms:3-Chloroperfluoropyridine;3-Chlorotetrafluoropyridine;5-Chlorotetrafluoropyridine;

Chemical Property of 3-Chloro-2,4,5,6-tetrafluoropyridine

Chemical Property:

• Appearance/Colour: Clear colourless liquid
• Vapor Pressure: 217mmHg at 25°C
• Refractive Index: n20/D 1.436(lit.)
• Boiling Point: 119.5 °C at 760 mmHg
• PKA: -11.94±0.28(Predicted)
• Flash Point: 42.1 °C
• PSA: 12.89000
• Density: 1.665 g/cm³
• LogP: 2.29140
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-Chloro-2,4,5,6-tetrafluoropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 3-Chloro-2,4,5,6-tetrafluoropyridine

There total 11 articles about 3-Chloro-2,4,5,6-tetrafluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

potassium fluoride (7789-23-3) + 2,3,4,5,6-pentachloropyridine (2176-62-7) → 3-chloro-2,4,5,6-tetrafluoropyridine (1735-84-8) + 3,5-dichloro-2,4,6-trifluoropyridine (1737-93-5,259875-95-1)

Guidance literature:

In neat (no solvent); 400 °C (18 h);;

Reference yield: 72.0%

3,5-dichloro-2,4,6-trifluoropyridine (1737-93-5,259875-95-1) → 3-chloro-2,4,5,6-tetrafluoropyridine (1735-84-8)

Guidance literature:

With potassium fluoride; In sulfolane; at 180 ℃; for 2.5h;

Reference yield: 65.0%

potassium fluoride (7789-23-3) + 2,3,4,5,6-pentachloropyridine (2176-62-7) → Pentafluoropyridine (700-16-3) + 3-chloro-2,4,5,6-tetrafluoropyridine (1735-84-8) + 3,5-dichloro-2,4,6-trifluoropyridine (1737-93-5,259875-95-1)

Guidance literature:

In neat (no solvent); autoclave, 470 °C (12 h), 2-fold molar excess of KF;;

upstream raw materials:

piperidine

2,3,4,5,6-pentachloropyridine

Pentafluoropyridine

3,5-dichloro-2,4,6-trifluoropyridine

Downstream raw materials:

3-cyclohexyltetrafluoropyridine

bicyclohexyl-2,2'-diene

2,3,4,6-tetrafluoropyridine

3-chloro-2,5,6-trifluoro-pyridine