Guanidine, N-[2-[[3,4,5,6-tetrahydro-3-[(4-methoxyphenyl)methyl]-5-[(4-nitrophenyl) methyl]-4,6-dioxo-1,3,5-triazin-2-yl]amino]ethyl]-

Base Information

• Chemical Name: Guanidine, N-[2-[[3,4,5,6-tetrahydro-3-[(4-methoxyphenyl)methyl]-5-[(4-nitrophenyl) methyl]-4,6-dioxo-1,3,5-triazin-2-yl]amino]ethyl]-
• CAS No.: 910114-08-8
• Molecular Formula: C21H24N8O5
• Molecular Weight: 468.472
• Mol file: 910114-08-8.mol

Synonyms:

Chemical Property of Guanidine, N-[2-[[3,4,5,6-tetrahydro-3-[(4-methoxyphenyl)methyl]-5-[(4-nitrophenyl) methyl]-4,6-dioxo-1,3,5-triazin-2-yl]amino]ethyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Guanidine, N-[2-[[3,4,5,6-tetrahydro-3-[(4-methoxyphenyl)methyl]-5-[(4-nitrophenyl) methyl]-4,6-dioxo-1,3,5-triazin-2-yl]amino]ethyl]-

There total 9 articles about Guanidine, N-[2-[[3,4,5,6-tetrahydro-3-[(4-methoxyphenyl)methyl]-5-[(4-nitrophenyl) methyl]-4,6-dioxo-1,3,5-triazin-2-yl]amino]ethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(2-amino-ethylamino)-1-(4-methoxy-benzyl)-3-(4-nitro-benzyl)-1H-[1,3,5]triazine-2,4-dione (910114-73-7) + 1H-pyrazole-1-carboximidamide hydrochloride (4023-02-3) → (2-(1-(4-methoxybenzyl)-5-(4-nitrobenzyl)-1,4,5,6-tetrahydro-4,6-dioxo-1,3,5-triazin-2-ylamino)ethyl)guanidine (910114-08-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 12h;

DOI:10.1016/j.ejmech.2014.05.030

Reference yield:

1-(4-methoxy-benzyl)-6-methylsulfanyl-3-(4-nitro-benzyl)-1H-[1,3,5]triazine-2,4-dione (910114-72-6) → (2-(1-(4-methoxybenzyl)-5-(4-nitrobenzyl)-1,4,5,6-tetrahydro-4,6-dioxo-1,3,5-triazin-2-ylamino)ethyl)guanidine (910114-08-8)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 12 h / 90 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 20 °C

With N-ethyl-N,N-diisopropylamine; In toluene; acetonitrile;

DOI:10.1016/j.ejmech.2014.05.030

Reference yield:

(4-nitro-benzyl)-urea (18740-35-7) → (2-(1-(4-methoxybenzyl)-5-(4-nitrobenzyl)-1,4,5,6-tetrahydro-4,6-dioxo-1,3,5-triazin-2-ylamino)ethyl)guanidine (910114-08-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 4 h / Reflux

2: sodium methylate / methanol / 0.5 h / 50 °C

3: sodium methylate / methanol / 3 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C

5: toluene / 12 h / 90 °C

6: N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 20 °C

With sodium methylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide; toluene; acetonitrile;

DOI:10.1016/j.ejmech.2014.05.030

upstream raw materials:

6-(2-amino-ethylamino)-1-(4-methoxy-benzyl)-3-(4-nitro-benzyl)-1H-[1,3,5]triazine-2,4-dione

1H-pyrazole-1-carboximidamide hydrochloride

(4-nitro-benzyl)-urea

1-(4-methoxy-benzyl)-6-methylsulfanyl-3-(4-nitro-benzyl)-1H-[1,3,5]triazine-2,4-dione