1-Pyrrolidinecarboxylic acid, 3-[[[4-methoxy-3-(3-methoxypropoxy)benzoyl](1-methylethyl)amino]meth yl]-4-[(methylamino)methyl]-, 1,1-dimethylethyl ester, (3R,4R)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 3-[[[4-methoxy-3-(3-methoxypropoxy)benzoyl](1-methylethyl)amino]meth yl]-4-[(methylamino)methyl]-, 1,1-dimethylethyl ester, (3R,4R)-
CAS No.:911113-32-1
Molecular Formula:C27H45N3O6
Molecular Weight:507.671
Hs Code.:

1-Pyrrolidinecarboxylic acid,
3-[[[4-methoxy-3-(3-methoxypropoxy)benzoyl](1-methylethyl)amino]meth
yl]-4-[(methylamino)methyl]-, 1,1-dimethylethyl ester, (3R,4R)-

Synonyms:

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Chemical Property of 1-Pyrrolidinecarboxylic acid, 3-[[[4-methoxy-3-(3-methoxypropoxy)benzoyl](1-methylethyl)amino]meth yl]-4-[(methylamino)methyl]-, 1,1-dimethylethyl ester, (3R,4R)-

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Technology Process of 1-Pyrrolidinecarboxylic acid, 3-[[[4-methoxy-3-(3-methoxypropoxy)benzoyl](1-methylethyl)amino]meth yl]-4-[(methylamino)methyl]-, 1,1-dimethylethyl ester, (3R,4R)-

There total 1 articles about 1-Pyrrolidinecarboxylic acid, 3-[[[4-methoxy-3-(3-methoxypropoxy)benzoyl](1-methylethyl)amino]meth yl]-4-[(methylamino)methyl]-, 1,1-dimethylethyl ester, (3R,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 895245-15-5
(3S,4R)-3-formyl-4-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 74-89-5
methylamine

: 911113-32-1
(3R,4R)-3-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-4-methylaminomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: (3S,4R)-3-formyl-4-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester; methylamine; In methanol; acetic acid; at 10 - 20 ℃; for 1h;

With sodium tetrahydroborate; In methanol; acetic acid; at 20 ℃; for 1.5h;

With water; In methanol; acetic acid;

Reference yield:

: 911113-32-1
(3R,4R)-3-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-4-methylaminomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester

: 103-80-0
phenylacetyl chloride

: 911113-24-1
(3R,4R)-3-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-4-[(methyl-phenylacetyl-amino)-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With triethylamine; at 0 - 20 ℃; for 1.5h;

Reference yield:

: 911113-32-1
(3R,4R)-3-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-4-methylaminomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester

: N-isopropyl-4-methoxy-3-(3-methoxy-propoxy)-N-{(3S,4S)-4-[(methyl-phenylacetyl-amino)-methyl]-pyrrolidin-3-ylmethyl}-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / 1.5 h / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 30 °C

With triethylamine; trifluoroacetic acid; In dichloromethane;