1,4-Piperidinedicarboxylic acid, 4-(4-bromophenyl)-, 1-(9H-fluoren-9-ylmethyl) ester

Base Information

• Chemical Name: 1,4-Piperidinedicarboxylic acid, 4-(4-bromophenyl)-, 1-(9H-fluoren-9-ylmethyl) ester
• CAS No.: 913542-81-1
• Molecular Formula: C27H24BrNO4
• Molecular Weight: 506.396

Synonyms:4-(4-Bromo-phenyl)-piperidine-1,4-dicarboxylic acid mono-(9H-fluoren-9-ylmethyl) ester;

Chemical Property of 1,4-Piperidinedicarboxylic acid, 4-(4-bromophenyl)-, 1-(9H-fluoren-9-ylmethyl) ester

Chemical Property:

• PSA: 66.84000
• LogP: 5.75430

Purity/Quality:

Fmoc-4-(4-bromophenyl)-piperidine-4-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-Piperidinedicarboxylic acid, 4-(4-bromophenyl)-, 1-(9H-fluoren-9-ylmethyl) ester

There total 3 articles about 1,4-Piperidinedicarboxylic acid, 4-(4-bromophenyl)-, 1-(9H-fluoren-9-ylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-(4-bromo-phenyl)-piperidine-4-carboxylic acid (913542-80-0) + (fluorenylmethoxy)carbonyl chloride (28920-43-6) → 4-(4-bromo-phenyl)-piperidine-1,4-dicarboxylic acid mono-(9H-fluoren-9-ylmethyl)ester (913542-81-1)

Guidance literature:

With sodium carbonate; In dichloromethane;

DOI:10.1016/j.tetlet.2006.06.070

Reference yield: 78.0%

4-(4-bromo-phenyl)-piperidine-4-carboxylic acid (913542-80-0) + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → 4-(4-bromo-phenyl)-piperidine-1,4-dicarboxylic acid mono-(9H-fluoren-9-ylmethyl)ester (913542-81-1)

Guidance literature:

4-(4-bromo-phenyl)-piperidine-4-carboxylic acid; N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide; With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 18h;

With hydrogenchloride; water; In tetrahydrofuran;

Reference yield:

tert-butyl 4-(4-bromophenyl)-4-cyano-piperidine-1-carboxylate (847615-14-9) → 4-(4-bromo-phenyl)-piperidine-1,4-dicarboxylic acid mono-(9H-fluoren-9-ylmethyl)ester (913542-81-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / H₂SO₄; H₂O / 100 °C

2: 98 percent / Na₂CO₃ / CH₂Cl₂

With sulfuric acid; water; sodium carbonate; In dichloromethane;

DOI:10.1016/j.tetlet.2006.06.070

upstream raw materials:

4-(4-bromo-phenyl)-piperidine-4-carboxylic acid

(fluorenylmethoxy)carbonyl chloride

tert-butyl 4-(4-bromophenyl)-4-cyano-piperidine-1-carboxylate

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

Downstream raw materials:

4-(4-bromo-phenyl)-4-chlorocarbonyl-piperidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

4-(4-bromo-phenyl)-4-(3-methoxy-phenoxymethyl)-piperidine-1-carboxylic acid tert-butyl ester

4-(3-methoxy-phenoxymethyl)-4-[4-(3-methyl-1H-pyrazol-4-yl)-phenyl]-piperidine

4-bromomethyl-4-(4-bromo-phenyl)-piperidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

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