2-Methoxy-1-formylpiperidine

Base Information

• Chemical Name: 2-Methoxy-1-formylpiperidine
• CAS No.: 61020-07-3
• Molecular Formula: C7H13 N O2
• Molecular Weight: 143.186
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID80369081
• Nikkaji Number: J410.673C
• Mol file: 61020-07-3.mol

Synonyms:2-Methoxy-1-formylpiperidine;61020-07-3;2-methoxypiperidine-1-carbaldehyde;1-formyl-2-methoxypiperidine;SCHEMBL1580134;DTXSID80369081;GMXVFNHJKDDELJ-UHFFFAOYSA-N;2-Methoxy-1-piperidinecarbaldehyde;AKOS006230486;FT-0640725

Chemical Property of 2-Methoxy-1-formylpiperidine

Chemical Property:

• Vapor Pressure: 0.0197mmHg at 25°C
• Refractive Index: 1.4610 (estimate)
• Boiling Point: 252.1°C at 760 mmHg
• Flash Point: 98.9°C
• PSA: 29.54000
• Density: 1.04g/cm³
• LogP: 1.17500
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 143.094628657
• Heavy Atom Count: 10
• Complexity: 116

Purity/Quality:

98%Min ^*data from raw suppliers

2-METHOXY-1-FORMYLPIPERIDINE 97.00% ^*data from reagent suppliers

Safty Information:

• Safety Statements: S24/25:Avoid contact with skin and eyes.

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1CCCCN1C=O

Technology Process of 2-Methoxy-1-formylpiperidine

There total 2 articles about 2-Methoxy-1-formylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-Formylpiperidine (2591-86-8) + methanol (67-56-1) → 1-formyl-2-methoxy-piperidine (61020-07-3)

Guidance literature:

With tetraethylammonium tosylate; Electrochemical reaction;

DOI:10.1016/j.tetlet.2004.09.036

Reference yield:

→ 1-formyl-2-methoxy-piperidine (61020-07-3)

Guidance literature:

1-Formyl-piperidin (5a), CH3OH, anodische Alkoxylierung, Tab. 2;

Reference yield: 92.0%

1-formyl-2-methoxy-piperidine (61020-07-3) + Benzenesulfinic acid (618-41-7) → 2-(phenylsulphonyl)-1-piperidinecarboxaldehyde (133535-64-5)

Guidance literature:

With calcium chloride; In dichloromethane; for 20h; Ambient temperature;

DOI:10.1016/S0040-4020(01)86388-2

upstream raw materials:

N-Formylpiperidine

methanol

Downstream raw materials:

N-formyl-2-(2,5-dimethylphenyl)-piperidine

2-(phenylsulphonyl)-1-piperidinecarboxaldehyde

N-formyl-2-(2,5-dimethoxyphenyl)-piperidine

N-formyl-2-(2,4,6-trimethylphenyl)-piperidine