4H-Pyrazolo[3,4-d]pyrimidin-4-one, 2-([1,1'-biphenyl]-4-ylmethyl)-2,5-dihydro-6-[(2-hydroxy-1,1-dimethylethyl )amino]-5-methyl-3-(phenylmethyl)-

Base Information

Chemical Name:4H-Pyrazolo[3,4-d]pyrimidin-4-one, 2-([1,1'-biphenyl]-4-ylmethyl)-2,5-dihydro-6-[(2-hydroxy-1,1-dimethylethyl )amino]-5-methyl-3-(phenylmethyl)-
CAS No.:916765-04-3
Molecular Formula:C30H31N5O2
Molecular Weight:493.608
Hs Code.:

4H-Pyrazolo[3,4-d]pyrimidin-4-one,
2-([1,1'-biphenyl]-4-ylmethyl)-2,5-dihydro-6-[(2-hydroxy-1,1-dimethylethyl
)amino]-5-methyl-3-(phenylmethyl)-

Synonyms:

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Chemical Property of 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 2-([1,1'-biphenyl]-4-ylmethyl)-2,5-dihydro-6-[(2-hydroxy-1,1-dimethylethyl )amino]-5-methyl-3-(phenylmethyl)-

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Technology Process of 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 2-([1,1'-biphenyl]-4-ylmethyl)-2,5-dihydro-6-[(2-hydroxy-1,1-dimethylethyl )amino]-5-methyl-3-(phenylmethyl)-

There total 7 articles about 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 2-([1,1'-biphenyl]-4-ylmethyl)-2,5-dihydro-6-[(2-hydroxy-1,1-dimethylethyl )amino]-5-methyl-3-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 916765-03-2
3-benzyl-2-(biphenyl-4-ylmethyl)-6-chloro-5-methyl-2H-pyrazolo[3,4-d]pyrimidin-4(5H)-one

: 124-68-5
2-Amino-2-methyl-1-propanol

: 916765-04-3
3-benzyl-2-(biphenyl-4-ylmethyl)-6-(1-hydroxy-2-methylpropan-2-ylimino)-5-methyl-6,7-dihydro-2H-pyrazolo[3,4-d]pyrimidin-4(5H)-one

Guidance literature:: In N,N-dimethyl-formamide; at 110 ℃;

Reference yield:

: 916765-00-9
6-(2-(biphenyl-4-ylmethylene)hydrazinyl)-1-(4-methoxybenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione

: 916765-04-3
3-benzyl-2-(biphenyl-4-ylmethyl)-6-(1-hydroxy-2-methylpropan-2-ylimino)-5-methyl-6,7-dihydro-2H-pyrazolo[3,4-d]pyrimidin-4(5H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: piperidine; acetic acid; N,N-dimethyl-formamide; tert-butyl alcohol / 36 h / 40 - 50 °C

1.2: 36 h / 40 - 45 °C

2.1: ammonium cerium(IV) nitrate / tetrahydrofuran; water / 20 °C

3.1: trichlorophosphate / 96 h / Heating / reflux

4.1: N,N-dimethyl-formamide / 110 °C

With ammonium cerium(IV) nitrate; trichlorophosphate; In tetrahydrofuran; piperidine; water; acetic acid; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 2565-47-1
1-methyl-2,4,6-pyrimidinetrione

: 916765-04-3
3-benzyl-2-(biphenyl-4-ylmethyl)-6-(1-hydroxy-2-methylpropan-2-ylimino)-5-methyl-6,7-dihydro-2H-pyrazolo[3,4-d]pyrimidin-4(5H)-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: trichlorophosphate / 5 h / 0 - 80 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 60 °C

3.1: hydrazine / methanol; ethanol / 3 h / Heating / reflux

4.1: ethyl acetate / 2 h / 20 °C

5.1: piperidine; acetic acid; N,N-dimethyl-formamide; tert-butyl alcohol / 36 h / 40 - 50 °C

5.2: 36 h / 40 - 45 °C

6.1: ammonium cerium(IV) nitrate / tetrahydrofuran; water / 20 °C

7.1: trichlorophosphate / 96 h / Heating / reflux

8.1: N,N-dimethyl-formamide / 110 °C

With ammonium cerium(IV) nitrate; potassium carbonate; hydrazine; trichlorophosphate; In tetrahydrofuran; piperidine; methanol; ethanol; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;