4-[(4-Fluorophenyl)(phenyl)methylidene]-1-(methanesulfonyl)piperidine

Base Information

Chemical Name:4-[(4-Fluorophenyl)(phenyl)methylidene]-1-(methanesulfonyl)piperidine
CAS No.:916976-44-8
Molecular Formula:C19H20FNO2S
Molecular Weight:345.438
Hs Code.:
DSSTox Substance ID:DTXSID60581401
Nikkaji Number:J2.409.864H

Synonyms:916976-44-8;DTXSID60581401;4-[(4-Fluorophenyl)(phenyl)methylidene]-1-(methanesulfonyl)piperidine

Suppliers and Price of 4-[(4-Fluorophenyl)(phenyl)methylidene]-1-(methanesulfonyl)piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 4-[(4-Fluorophenyl)(phenyl)methylidene]-1-(methanesulfonyl)piperidine

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:345.11987822
Heavy Atom Count:24
Complexity:542

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CS(=O)(=O)N1CCC(=C(C2=CC=CC=C2)C3=CC=C(C=C3)F)CC1

Technology Process of 4-[(4-Fluorophenyl)(phenyl)methylidene]-1-(methanesulfonyl)piperidine

There total 7 articles about 4-[(4-Fluorophenyl)(phenyl)methylidene]-1-(methanesulfonyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 515154-31-1
4-benzoyl-1-methanesulphonylpiperidine

: 352-13-6
4-flourophenylmagnesium bromide

: 916976-44-8
4-[1-(4-fluorophenyl)benzylidene]-1-(methylsulfonyl)-piperidine

Guidance literature:: 4-benzoyl-1-methanesulphonylpiperidine; 4-flourophenylmagnesium bromide; In tetrahydrofuran; at -78 ℃;

With boron trifluoride diethyl etherate; In dichloromethane; at 0 ℃;
DOI:10.1016/j.tetlet.2006.11.072

Reference yield:

: C₁₉H₂₂FNO₃S

: 916976-44-8
4-[1-(4-fluorophenyl)benzylidene]-1-(methylsulfonyl)-piperidine

Guidance literature:: With boron trifluoride diethyl etherate; In tetrahydrofuran; at 0 ℃; for 0.5h;
DOI:10.1002/jccs.200800070

Reference yield:

: 217487-18-8
1-methanesulfonylpiperidine-4-carboxylic acid ethyl ester

: 916976-44-8
4-[1-(4-fluorophenyl)benzylidene]-1-(methylsulfonyl)-piperidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminum hydride / tetrahydrofuran / 0 °C

2.1: pyridinium chlorochromate; Celite / CH₂Cl₂ / 20 °C

3.1: tetrahydrofuran / -78 °C

4.1: pyridinium chlorochromate; Celite / CH₂Cl₂ / 20 °C

5.1: tetrahydrofuran / -78 °C

5.2: 92 percent / boron trifluoride etherate / CH₂Cl₂ / 0 °C

With lithium aluminium tetrahydride; Celite; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; 3.1: Grignard addition / 5.1: Grignard addition;
DOI:10.1016/j.tetlet.2006.11.072