1-Piperidinecarboxylic acid, 4-amino-4-(4-chlorophenyl)-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 4-amino-4-(4-chlorophenyl)-, 1,1-dimethylethyl ester
CAS No.:917925-59-8
Molecular Formula:C16H23ClN2O2
Molecular Weight:310.824
Hs Code.:

Synonyms:4-AMINO-4-(4-CHLOROPHENYL)PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;

Suppliers and Price of 1-Piperidinecarboxylic acid, 4-amino-4-(4-chlorophenyl)-, 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Labseeker
4-Amino-4-(4-chloro-phenyl)-piperidine-1-carboxylicacidtert-butylester 95
10g
$ 4200.00

Labseeker
4-Amino-4-(4-chloro-phenyl)-piperidine-1-carboxylicacidtert-butylester 95
1g
$ 1833.00

American Custom Chemicals Corporation
4-AMINO-4-(4-CHLOROPHENYL)PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 95.00%
5MG
$ 503.51

Total 2 raw suppliers

Chemical Property of 1-Piperidinecarboxylic acid, 4-amino-4-(4-chlorophenyl)-, 1,1-dimethylethyl ester

Chemical Property:

PSA：55.56000
LogP:4.16310

Purity/Quality:

99% ^*data from raw suppliers

4-Amino-4-(4-chloro-phenyl)-piperidine-1-carboxylicacidtert-butylester 95 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 4-amino-4-(4-chlorophenyl)-, 1,1-dimethylethyl ester

There total 10 articles about 1-Piperidinecarboxylic acid, 4-amino-4-(4-chlorophenyl)-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 644981-94-2
4-(4-chloro-phenyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

: 24424-99-5
di-tert-butyl dicarbonate

: 917925-59-8
tert-butyl 4-amino-4-(4-chlorophenyl)piperidine-1-carboxylate

Guidance literature:: 4-(4-chloro-phenyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester; With triethylamine; isobutyl chloroformate; In tetrahydrofuran; at -10 ℃; for 1h;

With sodium azide; In tetrahydrofuran; water; at -10 - 0 ℃; for 20h;

di-tert-butyl dicarbonate; With hydrogenchloride; sodium hydroxide; water; more than 3 stages;

Reference yield:

: tert-butyl 4-(2-chloroacetamido)-4-(4-chlorophenyl)piperidine-1-carboxylate

: 917925-59-8
tert-butyl 4-amino-4-(4-chlorophenyl)piperidine-1-carboxylate

Guidance literature:: With thiourea; In ethanol; at 125 ℃; for 2.5h;

Reference yield:

: 235109-63-4
4-(4-chloro-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester

: 917925-59-8
tert-butyl 4-amino-4-(4-chlorophenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2.1: triethylamine / dichloromethane / 1 h / 0 °C

3.1: sulfuric acid / 2 h / 0 - 20 °C

3.2: 20 °C

4.1: thiourea / ethanol / 2.5 h / 125 °C

With sulfuric acid; triethylamine; thiourea; trifluoroacetic acid; In ethanol; dichloromethane;