235109-63-4

Basic information

• Product Name: 1-N-BOC-4-(4-CHLOROPHENYL)-4-HYDROXYPIPERIDINE
• Synonyms: 1-BOC-4-(4-CHLOROPHENYL)-4-HYDROXYPIPERIDINE;1-N-BOC-4-(4-CHLOROPHENYL)-4-HYDROXYPIPERIDINE
• CAS NO: 235109-63-4
• Molecular Formula: C₁₆H₂₂ClNO₃
• Molecular Weight: 311.807
• Mol File: 235109-63-4.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-N-BOC-4-(4-CHLOROPHENYL)-4-HYDROXYPIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-N-BOC-4-(4-CHLOROPHENYL)-4-HYDROXYPIPERIDINE(235109-63-4)
• EPA Substance Registry System: 1-N-BOC-4-(4-CHLOROPHENYL)-4-HYDROXYPIPERIDINE(235109-63-4)

Safety Data

• Hazardous Substances Data: 235109-63-4(Hazardous Substances Data)

Usage

Piperidine derivative

A chemical compound derived from piperidine, which is a heterocyclic organic compound that consists of a six-membered ring containing five carbon atoms and one nitrogen atom.

BOC protecting group

The compound contains a tert-butyloxycarbonyl (BOC) group, which is a protecting group used in organic synthesis to temporarily block the reactivity of an amine or alcohol functional group.

Intermediate in synthesis

This compound is primarily used as an intermediate in the synthesis of pharmaceutical drugs and other organic compounds, meaning it is a precursor that reacts further to form the final product.

Potential applications in medicinal chemistry

Due to its structural features, 1-N-BOC-4-(4-chlorophenyl)-4-hydroxypiperidine has potential applications in the development of new drugs and the study of medicinal chemistry.

Biological activity and pharmacological properties

The 4-(4-chlorophenyl)-4-hydroxypiperidine moiety in the compound may impart biological activity and pharmacological properties, making it a valuable building block for the synthesis of new drug candidates.

Versatile and important chemical compound

1-N-BOC-4-(4-chlorophenyl)-4-hydroxypiperidine is a significant compound in the fields of organic and medicinal chemistry due to its unique structure and potential applications.

Upstream product

• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 637-87-6 1-Chloro-4-iodobenzene 
• 39512-49-7 4-(4-chlorophenyl)-4-hydroxypiperidine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 106-39-8 bromochlorobenzene 

Downstream Products

• 30005-58-4 4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine 
• 725739-49-1 4-(4-chloro-phenyl)-3,6-dihydro-2H-pyridine-1-sulfonyl chloride 
• 235109-80-5 4-(4-chloro-phenyl)-4-methoxy-piperidine 
• 946593-11-9 tert-butyl 4-(4-chlorophenyl)piperidine-1-carboxylate 
• 26905-02-2 4-(4-chlorophenyl)piperidine 
• 771-99-3 4-phenylpiperidine 
• 34104-67-1 reduced haloperidol 
• 59995-68-5 Chlorohaloperidol 
• 5957-96-0 4-(4-chlorophenyl)pyridine 
• 917925-59-8 tert-butyl 4-amino-4-(4-chlorophenyl)piperidine-1-carboxylate 

Relevant articles and documents

Light-Mediated Formal Radical Deoxyfluorination of Tertiary Alcohols through Selective Single-Electron Oxidation with TEDA2+.

The synthesis of tertiary alkyl fluorides through a formal radical deoxyfluorination process is described herein. This light-mediated, catalyst-free methodology is fast and broadly applicable allowing for the preparation of C?F bonds from (hetero)benzylic, propargylic, and non-activated tertiary alcohol derivatives. Preliminary mechanistic studies support that the key step of the reaction is the single-electron oxidation of cesium oxalates—which are readily available from the corresponding tertiary alcohols—with in situ generated TEDA2+. (TEDA: N-(chloromethyl)triethylenediamine), a radical cation derived from Selectfluor.

Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines

A sustainable MAO-N biocatalyzed process for the synthesis of pyridines from aliphatic tetrahydropyridines (THP) has been developed. Pyridine compounds were synthesized under mild reaction conditions and with high conversion, exploiting MAO-N whole cells as aromatizing biocatalysts. The kinetic profile of the whole cell biocatalytic transformation was finally investigated via in situ 19F NMR.

METALLO-BETA-LACTAMASE INHIBITORS

The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.