Methyl 2,4-dibroMo-5-thiazole-carboxylate

Base Information

• Chemical Name: Methyl 2,4-dibroMo-5-thiazole-carboxylate
• CAS No.: 918164-43-9
• Molecular Formula: C5H3Br2NO2S
• Molecular Weight: 300.958
• Hs Code.: 2934999090
• Mol file: 918164-43-9.mol

Synonyms:2,4-Dibromo-thiazole-5-carboxylic acid methyl ester;5-Thiazolecarboxylic acid,2,4-dibromo-,methyl ester;methyl 2,4-dibromothiazole-5-carboxylate;methyl 2,4-dibromo-5-thiazole-carboxylate;

Chemical Property of Methyl 2,4-dibroMo-5-thiazole-carboxylate

Chemical Property:

• PSA: 67.43000
• LogP: 2.45470

Purity/Quality:

97% ^*data from raw suppliers

5-Thiazolecarboxylicacid,2,4-dibromo-,methylester 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2,4-dibroMo-5-thiazole-carboxylate

There total 1 articles about Methyl 2,4-dibroMo-5-thiazole-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methanol (67-56-1) + 2,4-dibromo-1,3-thiazole-5-carboxylic acid (139669-96-8) → methyl 2,4-dibromothiazole-5-carboxylate (918164-43-9)

Guidance literature:

With sulfuric acid; at 80 ℃; for 4h;

DOI:10.1039/b612235c

Reference yield: 92.0%

4-trifluoromethylphenylboronic dimethyl ester (873066-23-0) + methyl 2,4-dibromothiazole-5-carboxylate (918164-43-9) → methyl 4-bromo-2-(4-trifluoromethylphenyl)thiazole-5-carboxylate (918164-69-9)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 80 ℃; for 17h;

DOI:10.1039/b612235c

Reference yield:

methyl 2,4-dibromothiazole-5-carboxylate (918164-43-9) → (2,4-dibromo-1,3-thiazol-5-yl)methanol (170232-68-5)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 2.5h;

DOI:10.1039/b612235c

upstream raw materials:

methanol

2,4-dibromo-1,3-thiazole-5-carboxylic acid

Downstream raw materials:

methyl 4-bromo-2-(4-trifluoromethylphenyl)thiazole-5-carboxylate

(2,4-dibromo-1,3-thiazol-5-yl)methanol

PdBr(P(C₆H₅)3)2C₃NSBrCOOCH₃