Methyl 2,3,4-trifluoro-5-nitrobenzoate

Base Information

• Chemical Name: Methyl 2,3,4-trifluoro-5-nitrobenzoate
• CAS No.: 918321-24-1
• Molecular Formula: C8H4F3NO4
• Molecular Weight: 235.119
• Mol file: 918321-24-1.mol

Synonyms:2,3,4-trifluoro-5-nitrobenzoic acid methyl ester;Benzoic acid,2,3,4-trifluoro-5-nitro-,methyl ester;

Chemical Property of Methyl 2,3,4-trifluoro-5-nitrobenzoate

Chemical Property:

• PSA: 72.12000
• LogP: 2.32190

Purity/Quality:

97% ^*data from raw suppliers

Methyl2,3,4-trifluoro-5-nitrobenzoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2,3,4-trifluoro-5-nitrobenzoate

There total 1 articles about Methyl 2,3,4-trifluoro-5-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.9%

methanol (67-56-1) + 2,3,4-trifluoro-5-nitro-benzoic acid (197520-71-1) → methyl 2,3,4-trifluoro-5-nitrobenzoate (918321-24-1)

Guidance literature:

With thionyl chloride; at 60 ℃; for 4h;

Reference yield: 88.9%

methyl 2,3,4-trifluoro-5-nitrobenzoate (918321-24-1) → methyl 5-amino-2,3,4-trifluorobenzoate

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethyl acetate; at 20 ℃; for 3h;

Reference yield:

methyl 2,3,4-trifluoro-5-nitrobenzoate (918321-24-1) → methyl 2,4-diamino-3-fluoro-5-nitrobenzoate (918321-18-3)

Guidance literature:

With ammonia; In 1-methyl-pyrrolidin-2-one; water; at 15 - 80 ℃; for 8.5h; under 1875.19 Torr; Product distribution / selectivity;

upstream raw materials:

methanol

2,3,4-trifluoro-5-nitro-benzoic acid

Downstream raw materials:

methyl 2,4-diamino-3-fluoro-5-nitrobenzoate