2-(3-Bromo-4-methoxy-5-methylphenyl)-1,3-dioxolane

Base Information

Chemical Name:2-(3-Bromo-4-methoxy-5-methylphenyl)-1,3-dioxolane
CAS No.:918896-39-6
Molecular Formula:C11H13BrO3
Molecular Weight:273.126
Hs Code.:
DSSTox Substance ID:DTXSID10579959
Wikidata:Q82470650

Synonyms:918896-39-6;2-(3-Bromo-4-methoxy-5-methylphenyl)-1,3-dioxolane;1,3-Dioxolane, 2-(3-bromo-4-methoxy-5-methylphenyl)-;DTXSID10579959

Suppliers and Price of 2-(3-Bromo-4-methoxy-5-methylphenyl)-1,3-dioxolane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 2-(3-Bromo-4-methoxy-5-methylphenyl)-1,3-dioxolane

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:272.00481
Heavy Atom Count:15
Complexity:206

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=CC(=C1OC)Br)C2OCCO2

Technology Process of 2-(3-Bromo-4-methoxy-5-methylphenyl)-1,3-dioxolane

There total 3 articles about 2-(3-Bromo-4-methoxy-5-methylphenyl)-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 808750-22-3
3-bromo-4-methoxy-5-methyl benzaldehyde

: 107-21-1
ethylene glycol

: 918896-39-6
2-(3-bromo-4-methoxy-5-methyl phenyl)-1,3-dioxolane

Guidance literature:: With toluene-4-sulfonic acid; In benzene; for 9h; Heating;
DOI:10.1016/j.tet.2006.09.056

Reference yield:

: 578-58-5
2-methylmethoxybenzene

: 918896-39-6
2-(3-bromo-4-methoxy-5-methyl phenyl)-1,3-dioxolane

Guidance literature:: Multi-step reaction with 3 steps

1.1: POCl₃ / 0.25 h / cooling

1.2: 85 percent / dimethylformamide / 100 - 110 °C

2.1: 80 percent / N-bromosuccinimide / acetonitrile / 0 - 20 °C

3.1: 90 percent / PTSA monohydrate / benzene / 9 h / Heating

With N-Bromosuccinimide; toluene-4-sulfonic acid; trichlorophosphate; In acetonitrile; benzene; 1.2: Vilsmeier-Haack formylation;
DOI:10.1016/j.tet.2006.09.056

Reference yield:

: 32723-67-4
3-methyl-4-anisaldehyde

: 918896-39-6
2-(3-bromo-4-methoxy-5-methyl phenyl)-1,3-dioxolane

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / N-bromosuccinimide / acetonitrile / 0 - 20 °C

2: 90 percent / PTSA monohydrate / benzene / 9 h / Heating

With N-Bromosuccinimide; toluene-4-sulfonic acid; In acetonitrile; benzene;
DOI:10.1016/j.tet.2006.09.056