2-Chloro-N-(3,5-dimethylphenyl)-5-methoxy-4-methylaniline

Base Information

Chemical Name:2-Chloro-N-(3,5-dimethylphenyl)-5-methoxy-4-methylaniline
CAS No.:919090-39-4
Molecular Formula:C₁₆H₁₈ClNO
Molecular Weight:275.778
Hs Code.:
DSSTox Substance ID:DTXSID80582571
Wikidata:Q82474036

Synonyms:2-Chloro-N-(3,5-dimethylphenyl)-5-methoxy-4-methylaniline;919090-39-4;DTXSID80582571

Suppliers and Price of 2-Chloro-N-(3,5-dimethylphenyl)-5-methoxy-4-methylaniline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 2-Chloro-N-(3,5-dimethylphenyl)-5-methoxy-4-methylaniline

Chemical Property:

XLogP3:5.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:275.1076919
Heavy Atom Count:19
Complexity:276

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=CC(=C1)NC2=C(C=C(C(=C2)OC)C)Cl)C

Technology Process of 2-Chloro-N-(3,5-dimethylphenyl)-5-methoxy-4-methylaniline

There total 2 articles about 2-Chloro-N-(3,5-dimethylphenyl)-5-methoxy-4-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 556-96-7
5-bromo-1,3-xylene

: 133088-44-5
2-chloro-5-methoxy-4-methylaniline

: 919090-39-4
2-chloro-5-methoxy-4-methyl-N-(3,5-dimethylphenyl)aniline

Guidance literature:: With palladium diacetate; sodium t-butanolate; tri tert-butylphosphoniumtetrafluoroborate; In toluene; at 160 ℃; for 3h; microwave irradiation;
DOI:10.1021/jo061749g

Reference yield:

: 7206-70-4
4-amino-5-chloro-2-methoxybenzoic acid

: 919090-39-4
2-chloro-5-methoxy-4-methyl-N-(3,5-dimethylphenyl)aniline

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / BH₃*SMe₂ / chlorobenzene / 21 h / 80 - 130 °C

2: NaOtBu; Pd(OAc)2; [HP-t-Bu₃][BF₄] / toluene / 3 h / 160 °C / microwave irradiation

With palladium diacetate; dimethylsulfide borane complex; sodium t-butanolate; tri tert-butylphosphoniumtetrafluoroborate; In chlorobenzene; toluene; 2: Buchwald-Hartwig amination;
DOI:10.1021/jo061749g