915141-48-9

Basic information

• Product Name: 1,3-Dioxane-4-acetaldehyde, 2-phenyl-6-[3-(phenylmethoxy)propyl]-, (2S,4S,6S)-
• CAS NO: 915141-48-9
• Molecular Formula: C22H26O4
• Molecular Weight: 354.446
• Mol File: 915141-48-9.mol

Chemical Properties

• CAS DataBase Reference: 1,3-Dioxane-4-acetaldehyde, 2-phenyl-6-[3-(phenylmethoxy)propyl]-, (2S,4S,6S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxane-4-acetaldehyde, 2-phenyl-6-[3-(phenylmethoxy)propyl]-, (2S,4S,6S)-(915141-48-9)
• EPA Substance Registry System: 1,3-Dioxane-4-acetaldehyde, 2-phenyl-6-[3-(phenylmethoxy)propyl]-, (2S,4S,6S)-(915141-48-9)

Safety Data

• Hazardous Substances Data: 915141-48-9(Hazardous Substances Data)

Upstream product

• 943768-65-8 2-(2S,4R,6S)-6-[3-(benzyloxy)propyl]-2-phenyl-1,3-dioxan-4-yl-1-ethanol 
• 158110-04-4 (2S)-1,2-epoxy-5-benzyloxy-pentane 
• 112482-35-6 1-(benzyloxy)-4,5-epoxypentane 
• 127793-67-3 (S)‐7‐(benzyloxy)hept‐1‐en‐4‐ol 
• 876181-53-2 (E)-(S)-8-Benzyloxy-5-hydroxy-oct-2-enoic acid methyl ester 
• 921207-65-0 ethyl 2-{(2S,4S,6S)-6-[3-(benzyloxy)propyl]-2-phenyl-1,3-dioxan-4-yl}acetate 
• 915141-46-7 [(2S,4S,6S)-6-(3-Benzyloxy-propyl)-2-phenyl-[1,3]dioxan-4-yl]-acetic acid methyl ester 

Downstream Products

• 921207-71-8 (4R)-5-[(2S,4S,6S)-6-(3-benzyloxy-propyl)-2-phenyl-1,3-dioxan-4-yl]pent-1-en-4-ol 
• 915141-54-7 (2R,5S,6R,7R)-1-[(2S,4R,6S)-6-(3-Benzyloxy-propyl)-2-phenyl-[1,3]dioxan-4-yl]-8-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-6-(4-methoxy-benzyloxy)-5,7-dimethyl-octan-4-one 
• 915141-66-1 (2R,5S,6R,7R)-1-[(2S,4S,6S)-6-(3-Benzyloxy-propyl)-2-phenyl-[1,3]dioxan-4-yl]-2,8-bis-(tert-butyl-dimethyl-silanyloxy)-6-(4-methoxy-benzyloxy)-5,7-dimethyl-octan-4-one 
• 899827-95-3 (2S,5R,6R,7R)-1-[(2S,4S,6S)-6-(3-Benzyloxy-propyl)-2-phenyl-[1,3]dioxan-4-yl]-2,8-bis-(tert-butyl-dimethyl-silanyloxy)-6-(4-methoxy-benzyloxy)-5,7-dimethyl-octan-4-ol 
• 570397-58-9 (3S,5R,7R)-7-(benzyloxy)-3-[3-(benzyloxy)propyl]-5-hydroxy-14-methoxy-3,4,5,6,7,8-hexahydro-1H-2-benzoxacyclododecin-1-one 
• 921207-73-0 methyl 2-{(1E,4R)-4-benzyloxy-5-[(2S,4R,6S)-6-(3-benzyloxy-propyl)-2-phenyl-1,3-dioxan-4-yl]pent-1-enyl}-6-methoxy-benzoate 
• 921207-64-9 (4R)-4-benzyloxy-5-[(2S,4R,6S)-6-(3-benzyloxy-propyl)-2-phenyl-1,3-dioxan-4-yl]pent-1-ene 
• 921207-70-7 5-{(2S,4S,6S)-6-[3-(benzyloxy)propyl]-2-phenyl-1,3-dioxan-4-yl}-1-penten-4-one 

Relevant articles and documents

Stereoselective synthesis of a key intermediate of (-)-apicularen A

Progress towards the stereoselective formal synthesis of (-)-apicularen A is described. The convergent approach involves the assembly of aliphatic and aromatic fragments via Grubbs's cross metathesis. Other key reactions in the strategy include Sharpless

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A synthesis of the C1-C15 fragment of dolabelide C is reported. The key step is a diastereoselective Mukaiyama aldol reaction to form the C6-C7 bond, followed by reduction and deoxygenation of the carbonyl group at C5. The trisubstituted vinyl iodide is i

De novo formal synthesis of (-)-apicularen A via an iterative asymmetric hydration sequence

(Chemical Equation Presented) A de novo approach to the formal total synthesis of the macrolide natural product (-)-apicularen A has been achieved in 18 steps'from achiral starting materials. Both the absolute and relative stereochemistries of apicularen A were introduced by a Sharpless asymmetric dihydroxylation, a π-allyl-palladium catalyzed reduction, a stereoselective reduction, and a base-promoted transannulation to install the C-9 stereocenter.