2-Propenamide, 3-[2-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]oxy]-4-[2-[[tris(1-methylethyl )silyl]oxy]ethoxy]phenyl]-N-(pentylsulfonyl)-, (2E)-

Base Information

Chemical Name:2-Propenamide, 3-[2-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]oxy]-4-[2-[[tris(1-methylethyl )silyl]oxy]ethoxy]phenyl]-N-(pentylsulfonyl)-, (2E)-
CAS No.:926300-71-2
Molecular Formula:C31H44ClF3N2O6SSi
Molecular Weight:693.3
Hs Code.:

2-Propenamide,
3-[2-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]oxy]-4-[2-[[tris(1-methylethyl
)silyl]oxy]ethoxy]phenyl]-N-(pentylsulfonyl)-, (2E)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Propenamide, 3-[2-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]oxy]-4-[2-[[tris(1-methylethyl )silyl]oxy]ethoxy]phenyl]-N-(pentylsulfonyl)-, (2E)-

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Technology Process of 2-Propenamide, 3-[2-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]oxy]-4-[2-[[tris(1-methylethyl )silyl]oxy]ethoxy]phenyl]-N-(pentylsulfonyl)-, (2E)-

There total 7 articles about 2-Propenamide, 3-[2-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]oxy]-4-[2-[[tris(1-methylethyl )silyl]oxy]ethoxy]phenyl]-N-(pentylsulfonyl)-, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 926297-34-9
(2E)-3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-[(triisopropylsilyl)oxy]ethoxy)phenyl)acrylic acid

: 52960-14-2
1-pentylsulfonamide

: 926300-71-2
(2E)-3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-[(triisopropylsilyl)oxy]ethoxy)phenyl)-N-(pentylsulfonyl)acrylamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2012.03.036

Reference yield:

: 926295-27-4
ethyl (2E)-3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-hydroxyphenyl)acrylate

: 926300-71-2
(2E)-3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-[(triisopropylsilyl)oxy]ethoxy)phenyl)-N-(pentylsulfonyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 0.08 h / 50 °C

2.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 0.5 h / 50 °C

2.2: 20 °C

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 0 - 20 °C

With dmap; tributylphosphine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; ethanol; water; acetonitrile; 1.1: Mitsunobu reaction;
DOI:10.1016/j.bmc.2012.03.036

Reference yield:

: 926297-33-8
ethyl (2E)-3-(2-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)-4-(2-(triisopropylsilyloxy)ethoxy)phenyl)acrylate

: 926300-71-2
(2E)-3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-[(triisopropylsilyl)oxy]ethoxy)phenyl)-N-(pentylsulfonyl)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 0.5 h / 50 °C

1.2: 20 °C

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 0 - 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; ethanol; water; acetonitrile;
DOI:10.1016/j.bmc.2012.03.036