ethyl (2E)-3-(2-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)-4-(2-(triisopropylsilyloxy)ethoxy)phenyl)acrylate

Base Information

Chemical Name:ethyl (2E)-3-(2-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)-4-(2-(triisopropylsilyloxy)ethoxy)phenyl)acrylate
CAS No.:926297-33-8
Molecular Formula:C₂₈H₃₇ClF₃NO₅Si
Molecular Weight:588.139
Hs Code.:

Synonyms:ethyl (2E)-3-(2-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)-4-(2-(triisopropylsilyloxy)ethoxy)phenyl)acrylate

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Chemical Property of ethyl (2E)-3-(2-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)-4-(2-(triisopropylsilyloxy)ethoxy)phenyl)acrylate

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Technology Process of ethyl (2E)-3-(2-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)-4-(2-(triisopropylsilyloxy)ethoxy)phenyl)acrylate

There total 5 articles about ethyl (2E)-3-(2-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)-4-(2-(triisopropylsilyloxy)ethoxy)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 926295-27-4
ethyl (2E)-3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-hydroxyphenyl)acrylate

: 156730-17-5
2-((triisopropylsilyl)oxy)ethan-1-ol

: 926297-33-8
ethyl (2E)-3-(2-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)-4-(2-(triisopropylsilyloxy)ethoxy)phenyl)acrylate

Guidance literature:: With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; at 0 - 30 ℃; for 16h;

Reference yield:

: 95332-26-6
2-hydroxy-4-(methoxymethyloxy)benzaldehyde

: 926297-33-8
ethyl (2E)-3-(2-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)-4-(2-(triisopropylsilyloxy)ethoxy)phenyl)acrylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

1.2: 2 h / 0 - 50 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

2.2: 0.5 h / 0 - 20 °C

3.1: hydrogenchloride; water / acetone / 5 h / Reflux

4.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 0.08 h / 50 °C

With hydrogenchloride; tributylphosphine; water; sodium hydride; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; N,N-dimethyl-formamide; acetone; mineral oil; 2.1: Horner-Wadsworth-Emmons olefination / 2.2: Horner-Wadsworth-Emmons olefination / 4.1: Mitsunobu reaction;
DOI:10.1016/j.bmc.2012.03.036

Reference yield:

: 95-01-2
2,4-Dihydroxybenzaldehyde

: 926297-33-8
ethyl (2E)-3-(2-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)-4-(2-(triisopropylsilyloxy)ethoxy)phenyl)acrylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / acetone / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 2 h / 0 - 50 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

3.2: 0.5 h / 0 - 20 °C

4.1: hydrogenchloride; water / acetone / 5 h / Reflux

5.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 0.08 h / 50 °C

With hydrogenchloride; tributylphosphine; water; sodium hydride; potassium carbonate; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; N,N-dimethyl-formamide; acetone; mineral oil; 3.1: Horner-Wadsworth-Emmons olefination / 3.2: Horner-Wadsworth-Emmons olefination / 5.1: Mitsunobu reaction;
DOI:10.1016/j.bmc.2012.03.036