(2E)-3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-[(triisopropylsilyl)oxy]ethoxy)phenyl)acrylic acid

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Chemical Name:(2E)-3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-[(triisopropylsilyl)oxy]ethoxy)phenyl)acrylic acid
CAS No.:926297-34-9
Molecular Formula:C₂₆H₃₃ClF₃NO₅Si
Molecular Weight:560.085
Hs Code.:

Synonyms:(2E)-3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-[(triisopropylsilyl)oxy]ethoxy)phenyl)acrylic acid

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Chemical Property of (2E)-3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-[(triisopropylsilyl)oxy]ethoxy)phenyl)acrylic acid

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Technology Process of (2E)-3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-[(triisopropylsilyl)oxy]ethoxy)phenyl)acrylic acid

There total 6 articles about (2E)-3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-[(triisopropylsilyl)oxy]ethoxy)phenyl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 926297-33-8
ethyl (2E)-3-(2-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)-4-(2-(triisopropylsilyloxy)ethoxy)phenyl)acrylate

: 926297-34-9
(2E)-3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-[(triisopropylsilyl)oxy]ethoxy)phenyl)acrylic acid

Guidance literature:: ethyl (2E)-3-(2-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)-4-(2-(triisopropylsilyloxy)ethoxy)phenyl)acrylate; With sodium hydroxide; ethanol; water; In tetrahydrofuran; at 50 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 926295-27-4
ethyl (2E)-3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-hydroxyphenyl)acrylate

: 926297-34-9
(2E)-3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-[(triisopropylsilyl)oxy]ethoxy)phenyl)acrylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 0.08 h / 50 °C

2.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 0.5 h / 50 °C

2.2: 20 °C

With tributylphosphine; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; ethanol; water; 1.1: Mitsunobu reaction;
DOI:10.1016/j.bmc.2012.03.036

Reference yield:

: 888740-62-3
ethyl (2E)-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(methoxymethoxy)phenyl]acrylate

: 926297-34-9
(2E)-3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-[(triisopropylsilyl)oxy]ethoxy)phenyl)acrylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; water / acetone / 5 h / Reflux

2.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 0.08 h / 50 °C

3.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 0.5 h / 50 °C

3.2: 20 °C

With hydrogenchloride; tributylphosphine; water; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; ethanol; water; acetone; 2.1: Mitsunobu reaction;
DOI:10.1016/j.bmc.2012.03.036