(2E)-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-hydroxyethoxy)phenyl]-N-(pentylsulfonyl)acrylamide

Base Information

Chemical Name:(2E)-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-hydroxyethoxy)phenyl]-N-(pentylsulfonyl)acrylamide
CAS No.:926300-72-3
Molecular Formula:C₂₂H₂₄ClF₃N₂O₆S
Molecular Weight:536.957
Hs Code.:

Synonyms:(2E)-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-hydroxyethoxy)phenyl]-N-(pentylsulfonyl)acrylamide

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Chemical Property of (2E)-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-hydroxyethoxy)phenyl]-N-(pentylsulfonyl)acrylamide

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Technology Process of (2E)-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-hydroxyethoxy)phenyl]-N-(pentylsulfonyl)acrylamide

There total 7 articles about (2E)-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-hydroxyethoxy)phenyl]-N-(pentylsulfonyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 926300-71-2
(2E)-3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-[(triisopropylsilyl)oxy]ethoxy)phenyl)-N-(pentylsulfonyl)acrylamide

: 926300-72-3
(2E)-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-hydroxyethoxy)phenyl]-N-(pentylsulfonyl)acrylamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 50 ℃; for 0.5h;
DOI:10.1016/j.bmc.2012.03.036

Reference yield:

: 926295-27-4
ethyl (2E)-3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-hydroxyphenyl)acrylate

: 926300-72-3
(2E)-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-hydroxyethoxy)phenyl]-N-(pentylsulfonyl)acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 0.08 h / 50 °C

2.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 0.5 h / 50 °C

2.2: 20 °C

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 0 - 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 50 °C

With dmap; tributylphosphine; tetrabutyl ammonium fluoride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; ethanol; water; acetonitrile; 1.1: Mitsunobu reaction;
DOI:10.1016/j.bmc.2012.03.036

Reference yield:

: 926297-33-8
ethyl (2E)-3-(2-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)-4-(2-(triisopropylsilyloxy)ethoxy)phenyl)acrylate

: 926300-72-3
(2E)-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-hydroxyethoxy)phenyl]-N-(pentylsulfonyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 0.5 h / 50 °C

1.2: 20 °C

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 0 - 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 50 °C

With dmap; tetrabutyl ammonium fluoride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; ethanol; water; acetonitrile;
DOI:10.1016/j.bmc.2012.03.036