6-Chloropyrido[3,2-d]pyrimidine-2,4-diamine

Base Information

Chemical Name:6-Chloropyrido[3,2-d]pyrimidine-2,4-diamine
CAS No.:93684-07-2
Molecular Formula:C7H6ClN5
Molecular Weight:195.611
Hs Code.:
DSSTox Substance ID:DTXSID80538876
Wikidata:Q82414443
Mol file:93684-07-2.mol

Synonyms:6-chloropyrido[3,2-d]pyrimidine-2,4-diamine;93684-07-2;Pyrido[3,2-d]pyrimidine-2,4-diamine, 6-chloro-;2,4-diamino-6-chloro-pyrido[3,2-d]pyrimidine;SCHEMBL3922711;DTXSID80538876;GNENAHOTYMCVSR-UHFFFAOYSA-N;MFCD14585377;BP-11822;CS-0145571;2,4-diamino-6-chloropyrido[3,2-d]pyrimidine

Suppliers and Price of 6-Chloropyrido[3,2-d]pyrimidine-2,4-diamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 6-Chloropyrido[3,2-d]pyrimidine-2,4-diamine

Chemical Property:

PSA：92.17000
LogP:0.70280
XLogP3:0.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:0
Exact Mass:195.0311729
Heavy Atom Count:13
Complexity:190

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=NC2=C1N=C(N=C2N)N)Cl

Technology Process of 6-Chloropyrido[3,2-d]pyrimidine-2,4-diamine

There total 4 articles about 6-Chloropyrido[3,2-d]pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 29671-92-9
chloroformamidine hydrochloride

: 95095-84-4
3-amino-6-chloro-pyridine-2-carbonitrile

: 93684-07-2
6-chloropyrido[3,2-d]pyrimidine-2,4-diamine

Guidance literature:: chloroformamidine hydrochloride; 3-amino-6-chloro-pyridine-2-carbonitrile; In dimethylsulfon; at 165 ℃; for 0.5h;

With sodium hydroxide; In dimethylsulfon; water; at 20 ℃; pH=9 - 10;

Reference yield: 53.0%

: ethanimidamide hydrochloride

: 95095-84-4
3-amino-6-chloro-pyridine-2-carbonitrile

: 93684-07-2
6-chloropyrido[3,2-d]pyrimidine-2,4-diamine

Guidance literature:: With sodium methylate; In ethanol; at 80 ℃; for 4h;

Reference yield:

: 16013-85-7,136901-10-5
2,6-dicholoro-3-nitropyridine

: 93684-07-2
6-chloropyrido[3,2-d]pyrimidine-2,4-diamine

Guidance literature:: Multi-step reaction with 3 steps

1: NMP / 180 °C

2: Fe, HCl / methanol

3: dimethylsulfoxide

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; iron; In methanol; dimethyl sulfoxide;
DOI:10.1021/jm980206z