1,2,3,5-tetraphenyl-1H-pyrrole

Base Information

• Chemical Name: 1,2,3,5-tetraphenyl-1H-pyrrole
• CAS No.: 15345-47-8
• Molecular Formula: C28H21 N
• Molecular Weight: 371.481
• Mol file: 15345-47-8.mol

Synonyms:Pyrrole,1,2,3,5-tetraphenyl- (6CI,8CI); 1,2,3,5-Tetraphenyl-1H-pyrrole;1,2,3,5-Tetraphenylpyrrole; NSC 215017

Chemical Property of 1,2,3,5-tetraphenyl-1H-pyrrole

Chemical Property:

• Vapor Pressure: 1.61E-10mmHg at 25°C
• Boiling Point: 523.2°Cat760mmHg
• Flash Point: 270.2°C
• Density: 1.05g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2,3,5-tetraphenyl-1H-pyrrole

There total 40 articles about 1,2,3,5-tetraphenyl-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1,2,4-triphenylbutane-1,4-dione (4441-01-4) + aniline (62-53-3) → 1,2,3,5-tetraphenyl-pyrrole (15345-47-8)

Guidance literature:

With Dowex 50Wx₈-200 cationic exchange resin; In water; at 130 ℃; for 6h;

DOI:10.1002/jhet.317

Reference yield: 94.0%

[(1,3-diphenyl-2-propynyl)oxy]-trimethylsilane (59738-52-2) + benzylidene phenylamine (538-51-2) → 1,2,3,5-tetraphenyl-pyrrole (15345-47-8)

Guidance literature:

With phosphazene base-P₄-tert-butyl; In hexane; toluene; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1002/adsc.200800281

Reference yield: 81.0%

benzylidene phenylamine (538-51-2) + phenylacetylene (536-74-3) → 1,2,3,5-tetraphenyl-pyrrole (15345-47-8)

Guidance literature:

phenylacetylene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;

benzylidene phenylamine; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 10h; chemoselective reaction; Inert atmosphere;

DOI:10.1021/ol401369d

upstream raw materials:

1,2,4-triphenylbutane-1,4-dione

acetic acid

aniline

phenylhydrazine

Downstream raw materials:

N-phenyl benzoyl amide

1,2,4-triphenylbutane-1,4-dione

3,3,5-triphenyl-2,3-dihydro-1H-2-pyrrolone

benzoic acid

Refernces

• 1、 Rao, H. Surya Prakash,Jothilingam,Scheeren, Hans W.. "Microwave mediated facile one-pot synthesis of polyarylpyrroles from but-2-ene- and but-2-yne-1,4-diones". . p. 1625 - 1630. Retrieved 2004.
• 2、 Ai, Liankun,Ibrahim, Yusuf Ajibola,Li, Baolin,Li, Jiahui. "A convenient approach for the synthesis of substituted pyrroles by using phosphoric acid as a catalyst and their photophysical properties". . . Retrieved 2021/12/21.
• 3、 Zhu, Da-Liang,Wu, Qi,Young, David James,Wang, Hao,Ren, Zhi-Gang,Li, Hong-Xi. "Acyl radicals from α-keto acids using a carbonyl photocatalyst: Photoredox-catalyzed synthesis of ketones". supporting information. p. 6832 - 6837. Retrieved 2020/10/12.