N-(2-hydroxyphenyl)-2-phenylacetamide

Base Information

• Chemical Name: N-(2-hydroxyphenyl)-2-phenylacetamide
• CAS No.: 95384-58-0
• Molecular Formula: C14H13NO2
• Molecular Weight: 227.263
• DSSTox Substance ID: DTXSID30356860
• Nikkaji Number: J1.543.000A
• Wikidata: Q82136472
• ChEMBL ID: CHEMBL215634
• Mol file: 95384-58-0.mol

Synonyms:N-(2-hydroxyphenyl)-2-phenylacetamide;95384-58-0;Benzeneacetamide, N-(2-hydroxyphenyl)-;CHEMBL215634;SCHEMBL4433540;DTXSID30356860;AS-113;AKOS016617986;EN300-18149542;Z68195064

Chemical Property of N-(2-hydroxyphenyl)-2-phenylacetamide

Chemical Property:

• PSA: 52.82000
• LogP: 3.22290
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 227.094628657
• Heavy Atom Count: 17
• Complexity: 249

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CC(=O)NC2=CC=CC=C2O

Technology Process of N-(2-hydroxyphenyl)-2-phenylacetamide

There total 25 articles about N-(2-hydroxyphenyl)-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-amino-phenol (95-55-6) + phenylacetyl chloride (103-80-0) → N-(2-hydroxy-phenyl)-2-phenyl-acetamide (95384-58-0)

Guidance literature:

In ethyl acetate; Ambient temperature;

Reference yield: 78.0%

N,N,N--trimethyl--1--phenylmethanaminium trifluoromethanesulfonate (260783-80-0) + carbon monoxide (201230-82-2) + 2-amino-phenol (95-55-6) → N-(2-hydroxy-phenyl)-2-phenyl-acetamide (95384-58-0)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; triphenylphosphine; In dimethyl sulfoxide; toluene; at 100 ℃; Schlenk technique;

Reference yield: 74.0%

phenylacetylene (536-74-3) + 2-amino-phenol (95-55-6) → N-(2-hydroxy-phenyl)-2-phenyl-acetamide (95384-58-0)

Guidance literature:

With oxygen; potassium carbonate; copper(l) chloride; In methanol; acetonitrile; at 20 - 28 ℃; for 12h; under 760.051 Torr; regioselective reaction; Irradiation; Green chemistry;

DOI:10.1039/c9gc03608c

upstream raw materials:

2-amino-phenol

phenylacetyl chloride

1-acetoxy-2-(2-phenyl-acetylamino)-benzene

1-(2-phenyl-acetylamino)-2-propionyloxy-benzene

Downstream raw materials:

benzo[d]oxazol-2-yl(phenyl)methanone