Pentanedioic acid, 3-phenyl-, monomethyl ester

Base Information

• Chemical Name: Pentanedioic acid, 3-phenyl-, monomethyl ester
• CAS No.: 95592-75-9
• Molecular Formula: C₁₂H₁₄O₄
• Molecular Weight: 222.241
• Mol file: 95592-75-9.mol

Synonyms:

Chemical Property of Pentanedioic acid, 3-phenyl-, monomethyl ester

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pentanedioic acid, 3-phenyl-, monomethyl ester

There total 8 articles about Pentanedioic acid, 3-phenyl-, monomethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methanol (67-56-1) + 3-phenylglutaric acid anhydride (4160-80-9) → 3-phenyl-pentanedioic acid monomethyl ester (95592-75-9,101713-10-4,132015-40-8,91478-85-2)

Guidance literature:

With N-((1S)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)-3,5-bis(trifluoromethyl)benzenesulfonamide; In tert-butyl methyl ether; at -20 ℃; for 4h; optical yield given as %ee;

DOI:10.1002/anie.200801636

Reference yield: 97.0%

dimethyl 3-phenylpentanedioate (19006-47-4) → 3-phenyl-pentanedioic acid monomethyl ester (95592-75-9,101713-10-4,132015-40-8,91478-85-2)

Guidance literature:

With water; In 1,4-dioxane; at 5 ℃; pH=7; optical yield given as %ee; enantioselective reaction; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1016/j.tetasy.2011.11.012

Reference yield:

methanol (67-56-1) + 3-phenylglutaric acid anhydride (4160-80-9) → 3-phenyl-pentanedioic acid monomethyl ester (95592-75-9,101713-10-4,132015-40-8,91478-85-2) + 3-phenyl-pentanedioic acid monomethyl ester (101713-10-4)

Guidance literature:

With Novozym 435; In di-isopropyl ether; at 20 ℃; for 120h; Title compound not separated from byproducts;

DOI:10.1016/j.tetasy.2005.06.025

upstream raw materials:

2-Methoxypropene

(R)-3-(4-Methoxy-phenyl)-4,6-dioxo-2-phenyl-5-[1-phenyl-meth-(Z)-ylidene]-[1,3]oxazinane-2-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

dimethyl 3-phenylpentanedioate

methanol

Downstream raw materials:

(S)-4-phenyltetrahydro-2H-pyran-2-one

dimethyl 3-phenylpentanedioate

(S)-3-Phenyl-pentanedioic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester methyl ester

(4R)-4-phenyltetrahydro-2H-pyran-2-one