19006-47-4

Upstream product

• 67-56-1 methanol 
• 4165-96-2 3-phenylglutaric acid 
• 103-26-4 Methyl cinnamate 
• 96-32-2 bromoacetic acid methyl ester 
• 95592-75-9 3-phenyl-pentanedioic acid monomethyl ester 
• 74-88-4 methyl iodide 
• 103-36-6 ethyl 3-phenyl-2-propenoate 
• 77086-38-5 ketene t-butyldimethylsilyl methyl acetal 
• 103-26-4 methyl cinnamate 
• 201230-82-2 carbon monoxide 
• 98-83-9 isopropenylbenzene 

Downstream Products

• 863-69-4 1,5-Ditosyloxy-3-phenylpentan 
• 14149-31-6 4-phenylpiperidine-2,6-dione 
• 95592-75-9 3-phenyl-pentanedioic acid monomethyl ester 
• 101713-10-4 3-phenyl-pentanedioic acid monomethyl ester 
• 139156-62-0 (1S,2R,3R)-2-(Methoxycarbonyl)-3-phenylcyclopropane-1-carboxylic acid 
• 139156-62-0 (1R,2S,3S)-2-(Methoxycarbonyl)-3-phenylcyclopropane-1-carboxylic acid 
• 5682-61-1 (1S,2S)-2-phenylcyclopropanecarboxylic acid methyl ester 
• 71302-21-1 (4R)-4-phenyltetrahydro-2H-pyran-2-one 
• 61198-49-0 (S)-4-phenyltetrahydro-2H-pyran-2-one 
• 829-27-6 3-phenylpentane-1,5-diol 

Relevant academic research and scientific papers

Diversion of the Arbuzov reaction: Alkylation of C-Cl instead of phosphonic ester formation on the fullerene cage

We report an "inversed" Arbuzov reaction of the fullerene derivatives C60Ar5Cl with trialkyl phosphites P(OR)3 producing alkylated fullerene derivatives C60Ar5R (R = Me, Et, iPr, nBu) with almost quantitative yields. This reaction provides a convenient synthetic route for the preparation of a large variety of functionalized fullerene derivatives with tailored properties, e.g. water-soluble compounds demonstrating promising antiviral activities against HCMV, HSV1, HIV and several influenza virus strains.

NOVEL PIPERIDINE DERIVATIVE

The invention provides a compound of the following formula (1): wherein m, n, and p are independently an integer of 0 - 4, provided 3 ≤ m + n ≤ 8; X is nitrogen atom or a group of the formula: C-R15; Y is a substituted or unsubstituted aromatic group, etc.; R15, R1, R2, R3, R4 , R5, R6 and R7 are hydrogen atom, a substituted or unsubstituted alkyl group, etc.; and Z is hydrogen atom, cyano group, etc., or a prodrug thereof, or a pharmaceutically acceptable salt thereof, which exhibits an action for enhancing LDL receptor expression, and is useful as a medicament for treating hyperlipidemia, atherosclerosis, etc.

Lithium Cobalt-Bis-Dicarbollide: A Novel Lewis Acid Catalyst for the Conjugate Addition of Silyl Ketene Acetals to Hindered α,β-Unsaturated Carbonyl Compounds

The novel Lewis acid, lithium cobalt-bis-carbollide (1), in which the lithium ion is weakly coordinated to the Co(B9C2H11)2(1-) anion, is an effective, soluble catalyst for Mukaiyama-Michael reactions.

l-Menthyl (2S)-2-phenyl-3-(p-anisyl)-(5Z)-benzylidene-4,6-dioxo-1,3-oxazine-2-ca rboxylate: A new chiral heterodiene and Michael acceptor

The title homochiral oxazinedione has been synthesized from l-menthyl phenylglyoxylate in three steps and found to exhibit high diastereofacial selectivity (≥99%) when used as heterodiene and Michael acceptor.

184. Stereoselective Hydrolysis of Substituted Cyclopropanedicarboxylates with Pig Liver Esterase

The hydrolysis of the meso-cyclopropane-1,2-dicarboxylates 1a-3a, 4, 5a, 6a, and 9, containing various substituents at C(3), and of the rac-3-phenylcyclopropane-1,2-dicarboxylates 7a, 8a, and 10 with pig liver esterase (PLE) is described.The stereoselectivity and absolute configurations of the products were determined.An interpretation of results was attempted on the basis of a recent active-site model for PLE.

SYNTHESIS OF 4-SUBSTITUTED GLUTARIMIDES BY FREE RADICAL ADDITION OF IODOACETAMIDE TO α,β-UNSATURATED ESTERS

Free radical addition of either methyl bromoacetate or iodoacetamide to an α,β-unsaturated ester gave the 4-substituted glutarate or glutarimide respectively, whereas the radical cyclisation of N-bromoacetyl crotonamide gave the 2-substituted succinimide.