Z-D-Dap-OMe.HCl

Base Information

• Chemical Name: Z-D-Dap-OMe.HCl
• CAS No.: 96192-93-7
• Molecular Formula: C₁₂H₁₆N₂O₄*ClH
• Molecular Weight: 288.731
• Mol file: 96192-93-7.mol

Synonyms:Methyl (R)-3-amino-2-[[(benzyloxy)carbonyl]amino]propanoate hydrochloride;Z-D-DAP-OME*HCL N-ALPHA-BENZYLOXYCARBONYL-D-2,3-DIAMINOPROPIONIC ACID METHYL ESTER HYDROCHLORIDE;D-Alanine, 3-amino-N-[(phenylmethoxy)carbonyl]-, methyl ester, monohydrochloride;

Chemical Property of Z-D-Dap-OMe.HCl

Chemical Property:

• Melting Point: 169-171 °C
• PSA: 90.65000
• LogP: 2.30630

Purity/Quality:

98% ^*data from raw suppliers

(R)-Methyl3-amino-2-(((benzyloxy)carbonyl)amino)propanoatehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (R)-Methyl 3-amino-2-(((benzyloxy)carbonyl)amino)propanoate hydrochloride is used in the preparation of Diacylglycerol acyltransferase-1 inhibitors.

Technology Process of Z-D-Dap-OMe.HCl

There total 13 articles about Z-D-Dap-OMe.HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 2-(R)-amino>-3-aminopropionic acid (62234-37-1) → methyl (R)-3-amino-2-(((benzyloxy)carbonyl)amino)propanoate hydrochloride (96192-93-7)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃;

Reference yield: 99.0%

methanol (67-56-1) + (S)-3-amino-2-(((benzyloxy)carbonyl)amino)propanoic acid (35761-26-3) → methyl (2S)-3-amino-2-{[(benzyloxy)carbonyl]amino}propanoate hydrochloride (35761-27-4,96192-93-7)

Guidance literature:

With hydrogenchloride; for 12h; Ambient temperature;

DOI:10.1021/jm980071x

Reference yield: 98.0%

(S)-methyl 3-amino-2-(((benzyloxy)carbonyl)amino)propanoate (75760-11-1) → methyl (2S)-3-amino-2-{[(benzyloxy)carbonyl]amino}propanoate hydrochloride (35761-27-4,96192-93-7)

Guidance literature:

With hydrogenchloride; In methanol;

upstream raw materials:

methanol

(S)-3-amino-2-(((benzyloxy)carbonyl)amino)propanoic acid

N-benzyloxycarbonyl-L-asparagine

(L)-N-Z-azidoalanine methyl ester

Downstream raw materials:

(S)-Methyl 3-((2-(benzyloxy)-2-oxoethyl)amino)-2-(((benzyloxy)carbonyl)amino)propaneate

C₂₁H₁₉BrN₄O₇