4-Benzyloxy-DL-phenylalanine

Base Information

• Chemical Name: 4-Benzyloxy-DL-phenylalanine
• CAS No.: 96612-91-8
• Molecular Formula: C16H17NO3
• Molecular Weight: 271.316
• Hs Code.: 2922500090
• Mol file: 96612-91-8.mol

Synonyms:(S)-2-Amino-3-(4-benzyloxy-phenyl)-propionic acid;p-benzyloxyphenylalanine;2R-amino-3-(4-benzyloxyphenyl)propionic acid;2-amino-3-(4-benzyloxyphenyl)propanoic acid;DL-3-(4-Benzyloxyphenyl)alanin;L-Tyr(Bzl);O-benzyl-tyrosine;

Chemical Property of 4-Benzyloxy-DL-phenylalanine

Chemical Property:

• Boiling Point: 456.1±40.0 °C(Predicted)
• PKA: 2.24±0.10(Predicted)
• PSA: 72.55000
• Density: 1?+-.0.06 g/cm3(Predicted)
• LogP: 2.92030

Purity/Quality:

98.5% ^*data from raw suppliers

4-Benzyloxy-DL-phenylalanine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Benzyloxy-DL-phenylalanine

There total 3 articles about 4-Benzyloxy-DL-phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl bromide (100-39-0) + ?Tyr (556-02-5,556-03-6,34537-57-0,55520-40-6,96946-98-4,60-18-4,18875-48-4,25619-78-7,30704-25-7) → (S)-2-amino-3-(4benzyloxyphenyl)propionic acid (96612-91-8)

Guidance literature:

?Tyr; With sodium hydroxide; copper(II) sulfate; In water; at 60 ℃; for 1.5h;

benzyl bromide; In methanol; water; at 20 ℃;

Reference yield:

N-methylcyclohexylamine (100-60-7) + O-benzyl-N-tert-butoxycarbonyl-L-tyrosine (2130-96-3,54784-43-9) + chloroformic acid ethyl ester (541-41-3) → (S)-2-amino-3-(4benzyloxyphenyl)propionic acid (96612-91-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; hexane;

Reference yield:

→ (S)-2-amino-3-(4benzyloxyphenyl)propionic acid (96612-91-8)

Guidance literature:

Tyrosin, 1) NaOH, Δ, 2) CuSO4, C6H5CH2Cl, Δ, 3) Trilon B, Δ;

DOI:10.1007/BF00930175

upstream raw materials:

N-methylcyclohexylamine

O-benzyl-N-tert-butoxycarbonyl-L-tyrosine

chloroformic acid ethyl ester

benzyl bromide

Downstream raw materials:

(S)-3-(4-Benzyloxy-phenyl)-2-[(S)-2-((S)-2-tert-butoxycarbonylamino-propionyloxy)-3-methyl-butyrylamino]-propionic acid

2-hydroxy-3-(4-benzyloxyphenyl)propanoic acid

4-(4-Benzyloxy-benzyl)-oxazolidine-2,5-dione

2-Amino-3-(4-benzyloxy-phenyl)-propionic acid octyl ester; hydrochloride