2-(2-CHLOROPHENYL)-4,5-DIHYDRO-4,4-DIMETHYLOXAZOLE

Base Information

• Chemical Name: 2-(2-CHLOROPHENYL)-4,5-DIHYDRO-4,4-DIMETHYLOXAZOLE
• CAS No.: 98191-99-2
• Molecular Formula: C11H12ClNO
• Molecular Weight: 209.675
• Hs Code.: 2934999090
• Mol file: 98191-99-2.mol

Synonyms:AB3560;

Chemical Property of 2-(2-CHLOROPHENYL)-4,5-DIHYDRO-4,4-DIMETHYLOXAZOLE

Chemical Property:

• PSA: 21.59000
• LogP: 2.33100

Purity/Quality:

97% ^*data from raw suppliers

2-(2-Chlorophenyl)-4,4-dimethyl-4,5-dihydrooxazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-CHLOROPHENYL)-4,5-DIHYDRO-4,4-DIMETHYLOXAZOLE

There total 9 articles about 2-(2-CHLOROPHENYL)-4,5-DIHYDRO-4,4-DIMETHYLOXAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-Amino-2-methyl-1-propanol (124-68-5) + (1H-benzo[d][1,2,3]triazol-1-yl)(2-chlorophenyl)methanone (30457-12-6) → 2-(2-chlorophenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole (98191-99-2)

Guidance literature:

2-Amino-2-methyl-1-propanol; (1H-benzo[d][1,2,3]triazol-1-yl)(2-chlorophenyl)methanone; In chloroform; at 80 ℃; for 0.166667h; under 206.859 - 517.148 Torr; microwave irradiation;

With thionyl chloride; In chloroform; at 80 ℃; for 0.0333333h; microwave irradiation;

DOI:10.1021/jo0355092

Reference yield: 92.0%

2-Amino-2-methyl-1-propanol (124-68-5) + salicylic acid (69-72-7,25496-36-0,8052-31-1) → 2-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-phenol (163165-91-1) + 2-(2-chlorophenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole (98191-99-2)

Guidance literature:

salicylic acid; With pyridine; 1,3,5-trichloro-2,4,6-triazine; In dichloromethane; at 0 ℃; for 0.25h;

2-Amino-2-methyl-1-propanol; With indium; In dichloromethane; at 20 ℃; for 30h;

DOI:10.1016/j.tetlet.2009.07.032

Reference yield: 87.0%

2-Amino-2-methyl-1-propanol (124-68-5) + ortho-chlorobenzoic acid (118-91-2) → 2-(2-chlorophenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole (98191-99-2)

Guidance literature:

ortho-chlorobenzoic acid; With thionyl chloride; In N,N-dimethyl-formamide; toluene; at 20 - 70 ℃; for 4h;

2-Amino-2-methyl-1-propanol; With triethylamine; In dichloromethane; at -10 - 20 ℃; for 2h; Temperature; Time;

upstream raw materials:

2-(2-chloro-benzoylamino)-2-methyl-propan-1-ol

2-Amino-2-methyl-1-propanol

(1H-benzo[d][1,2,3]triazol-1-yl)(2-chlorophenyl)methanone

ortho-chlorobenzoic acid

Downstream raw materials:

2-(2-Butylphenyl)-4,4-dimethyl-2-oxazoline

4,4-dimethyl-2-(4'-methyl-biphenyl-2-yl)-4,5-dihydrooxazole

2-(naphthalene-1-yl)benzaldehyde

2-(4-methoxyphenyl)benzaldehyde