N-{7-[2-(4-chlorobiphenyl)-5,5-dimethylcyclohex-1-enylmethyl]-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl}-4-((R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-3-trifluoromethanesulfonylbenzenesulfonamide

Base Information

Chemical Name:N-{7-[2-(4-chlorobiphenyl)-5,5-dimethylcyclohex-1-enylmethyl]-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl}-4-((R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-3-trifluoromethanesulfonylbenzenesulfonamide
CAS No.:1274802-46-8
Molecular Formula:C₄₈H₅₉ClF₃N₇O₅S₃
Molecular Weight:1002.69
Hs Code.:

N-{7-[2-(4-chlorobiphenyl)-5,5-dimethylcyclohex-1-enylmethyl]-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl}-4-((R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-3-trifluoromethanesulfonylbenzenesulfonamide

Synonyms:N-{7-[2-(4-chlorobiphenyl)-5,5-dimethylcyclohex-1-enylmethyl]-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl}-4-((R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-3-trifluoromethanesulfonylbenzenesulfonamide

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Chemical Property of N-{7-[2-(4-chlorobiphenyl)-5,5-dimethylcyclohex-1-enylmethyl]-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl}-4-((R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-3-trifluoromethanesulfonylbenzenesulfonamide

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Technology Process of N-{7-[2-(4-chlorobiphenyl)-5,5-dimethylcyclohex-1-enylmethyl]-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl}-4-((R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-3-trifluoromethanesulfonylbenzenesulfonamide

There total 9 articles about N-{7-[2-(4-chlorobiphenyl)-5,5-dimethylcyclohex-1-enylmethyl]-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl}-4-((R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-3-trifluoromethanesulfonylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 1274804-96-4
1-[2-(4-chloro-phenyl)-5.5-dimethyl-cyclohex-1-enylmethyl]-piperidin-4-one

: 1274804-70-4
(R)-4-(4-morpholino-1-(phenylthio)butan-2-ylamino)-N-(5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-3-(trifluoromethylsulfonyl)-benzenesulfonamide

: 1274802-46-8
N-{7-[2-(4-chlorobiphenyl)-5,5-dimethylcyclohex-1-enylmethyl]-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl}-4-((R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-3-trifluoromethanesulfonylbenzenesulfonamide

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 45 ℃; for 12h;

Reference yield:

: 71233-25-5
ethyl 1-tert-butoxycarbonyl-3-oxopiperidine-4-carboxylate

: 1274802-46-8
N-{7-[2-(4-chlorobiphenyl)-5,5-dimethylcyclohex-1-enylmethyl]-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl}-4-((R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-3-trifluoromethanesulfonylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium ethanolate / ethanol / 5 h / 70 °C

2.1: triphenylphosphine / 1,2-dichloro-ethane

2.2: 2.5 h / 70 °C

3.1: DavePhos; caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.58 h / 180 °C / Microwave irradiation

4.1: hydrogenchloride / dichloromethane; diethyl ether / 3 h / 0 - 20 °C

5.1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 12 h / 45 °C

With hydrogenchloride; sodium ethanolate; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; triphenylphosphine; DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; diethyl ether; ethanol; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 1679-18-1
4-Chlorophenylboronic acid

: 1274802-46-8
N-{7-[2-(4-chlorobiphenyl)-5,5-dimethylcyclohex-1-enylmethyl]-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl}-4-((R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-3-trifluoromethanesulfonylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.2 h / 100 °C / Inert atmosphere; Microwave irradiation

2.1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 0.17 h / 20 °C

2.2: 16 h / 20 °C

3.1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 12 h / 45 °C

With sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; 1,2-dichloro-ethane;