2-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine

Base Information

• Chemical Name: 2-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine
• CAS No.: 1060815-90-8
• Molecular Formula: C6H3ClIN3
• Molecular Weight: 279.467
• Hs Code.: 2933990090
• Mol file: 1060815-90-8.mol

Synonyms:2-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine;2-Chloro-5-iodo-7H-pyrrol...;2-chloro-5-iodo-7H-pyrrolo[2

Chemical Property of 2-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine

Chemical Property:

• PKA: 9.68±0.50(Predicted)
• PSA: 41.57000
• Density: 2.284±0.06 g/cm3(Predicted)
• LogP: 2.21590
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine

There total 1 articles about 2-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-chloro-7H-pyrrolo[2,3-d]pyrimidine (335654-06-3) → 2-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (1060815-90-8)

Guidance literature:

With iodine; potassium hydroxide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;

Reference yield: 92.0%

2-bromo-2-methylpropionic acid methyl ester (23426-63-3) + 2-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (1060815-90-8) → methyl 2-(2-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-methylpropanoate

Guidance literature:

With caesium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 60 ℃; for 19h;

Reference yield: 87.0%

2-iodo-propane (75-30-9) + 2-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (1060815-90-8) → 2-chloro-5-iodo-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

upstream raw materials:

2-chloro-7H-pyrrolo[2,3-d]pyrimidine

Downstream raw materials:

C₁₃H₉ClIN₃O₂S

C₁₂H₇ClIN₃O₂S

N-{5-[2-amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]-2-cyanophenyl}-2-(4-trifluoromethylphenyl)acetamide

N-(5-{2-amino-7-[2-(tert-butyldimethylsilanyloxy)-1,1-dimethylethyl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl}-2-cyanophenyl)-2-(4-trifluoromethylphenyl)acetamide

Refernces

• 1、 -. "PYRROLO(PYRAZOLO)PYRIMIDINE DERIVATIVE AS LRRK2 INHIBITOR". Paragraph 0073. . Retrieved 2020/11/23.
• 2、 -. "PYRROLO[2,3-D]PYRIMIDINE TROPOMYOSIN-RELATED KINASE INHIBITORS". Page/Page column 134. . Retrieved 2014/04/18.