1-Morpholin-4-yl-1-phenylacetone

Base Information

• Chemical Name: 1-Morpholin-4-yl-1-phenylacetone
• CAS No.: 19134-49-7
• Molecular Formula: C13H17 N O2
• Molecular Weight: 219.283
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID40407231
• Nikkaji Number: J2.430.464G
• Mol file: 19134-49-7.mol

Synonyms:1-morpholin-4-yl-1-phenylacetone;19134-49-7;1-morpholin-4-yl-1-phenylpropan-2-one;1-Morpholino-1-phenylpropan-2-one;1-(morpholin-4-yl)-1-phenylpropan-2-one;2-Propanone, 1-(4-morpholinyl)-1-phenyl-;starbld0018822;SCHEMBL12174899;DTXSID40407231;AKOS027379098;EN300-09856;Z56347090;(-)-trans-1-Methyl-3-hydroxymethyl-4-(4-fluorophenyl)piperdine

Chemical Property of 1-Morpholin-4-yl-1-phenylacetone

Chemical Property:

• Vapor Pressure: 0.000701mmHg at 25°C
• Boiling Point: 308°Cat760mmHg
• Flash Point: 140.1°C
• PSA: 29.54000
• Density: g/cm³
• LogP: 1.58680
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 219.125928785
• Heavy Atom Count: 16
• Complexity: 230

Purity/Quality:

98%Min ^*data from raw suppliers

1-MORPHOLIN-4-YL-1-PHENYLACETONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C(C1=CC=CC=C1)N2CCOCC2

Technology Process of 1-Morpholin-4-yl-1-phenylacetone

There total 5 articles about 1-Morpholin-4-yl-1-phenylacetone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

α-morpholino-β-methylstyrene (66217-92-3) → α-Morpholino α-phenyl acetone (19134-49-7)

Guidance literature:

With 3,3-dimethyldioxirane; In dichloromethane; acetone; at -70 ℃; for 1.25h;

Reference yield: 14.0%

morpholine (110-91-8,99108-56-2) + 1-bromo-1-phenyl-2-propanone (23022-83-5) → α-Morpholino α-phenyl acetone (19134-49-7)

Guidance literature:

Reference yield: 8.0%

morpholine (110-91-8,99108-56-2) + 2,2-dichloropropanal (27313-32-2) + phenylboronic acid (98-80-6) → 2-(morpholin-4-yl)-1-phenylpropan-1-one (5650-45-3) + α-Morpholino α-phenyl acetone (19134-49-7)

Guidance literature:

In toluene; at 110 ℃; for 18h;

DOI:10.1055/s-2007-965880

upstream raw materials:

morpholine

1-bromo-1-phenyl-2-propanone

4-(1-phenyl-propenyl)-morpholine

α-morpholino-β-methylstyrene

Downstream raw materials:

(1R,2S)-1-morpholino-1-phenylpropan-2-ol

Refernces

• 1、 Xie, Jian-Hua,Liu, Sheng,Kong, Wei-Ling,Bai, Wen-Ju,Wang, Xiao-Chen,et al.. "Highly enantioselective and diastereoselective synthesis of chiral aminoalcohols by ruthenium-catalyzed asymmetric hydrogenation of α-ami no aliphatic ketones". supporting information; experimental part. p. 4222 - 4223. Retrieved 2009/09/30.
• 2、 Blau, K.,Burgemeister, I.,Grasnick, J.,Voerckel, V.. "Studies on the Oxidation of Enamines with Molecular Oxygen. III Oxidation of Some Amino Styrenes". . p. 455 - 466. Retrieved 2007/10/02.