5650-45-3

Basic information

• Product Name: 1-Propanone, 2-(4-morpholinyl)-1-phenyl-
• CAS NO: 5650-45-3
• Molecular Formula: C13H17NO2
• Molecular Weight: 219.283
• Mol File: 5650-45-3.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 2-(4-morpholinyl)-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 2-(4-morpholinyl)-1-phenyl-(5650-45-3)
• EPA Substance Registry System: 1-Propanone, 2-(4-morpholinyl)-1-phenyl-(5650-45-3)

Safety Data

• Hazardous Substances Data: 5650-45-3(Hazardous Substances Data)

Usage

Chemical class

Ketone derivative

Structural features

A phenyl group and a morpholine ring attached to the second carbon atom of the propanone backbone

Uses

Versatile building block in organic synthesis, intermediate in the synthesis of pharmaceuticals and biologically active compounds

Neurotoxic effects

Can be metabolized into a compound that selectively destroys dopaminergic neurons in the brain, potential role in parkinsonism.

Upstream product

• 110-91-8 morpholine 
• 70-11-1 α-bromoacetophenone 
• 93-55-0 1-phenyl-propan-1-one 
• 637-50-3 1-phenylpropene 
• 120972-13-6 N-iodomorpholine-hydrogen iodide 
• 6084-15-7 2-iodo-1-phenylpropan-1-one 
• 21120-36-5 1-fluoroethyl phenyl ketone 
• 27313-32-2 2,2-dichloropropanal 
• 98-80-6 phenylboronic acid 
• 66217-95-6 β-Morpholino-β-methyl styrene 
• 3626-56-0 2-morpholinopropanenitrile 
• 591-51-5 phenyllithium 
• 108-86-1 bromobenzene 
• 93-54-9 1-Phenyl-1-propanol 

Downstream Products

• 93764-54-6 2,6-dimethyl-3,5-diphenylpyrazine 
• 54600-85-0 2,5-dimethyl-3,6-diphenylpyrazine 
• 579-07-7 1-Phenylpropane-1,2-dione 
• 115045-14-2 (1R,2S)-2-morpholino-1-phenylpropan-1-ol 
• 13739-49-6 2,5⁽⁴⁾-dimethyl-4⁽⁵⁾-phenylimidazole 

Relevant articles and documents

Enantioselective and Diastereoselective Construction of Chiral Amino Alcohols by Iridium-f-Amphox-Catalyzed Asymmetric Hydrogenation via Dynamic Kinetic Resolution

The iridium-f-amphox-catalyzed asymmetric hydrogenation of racemic α-amino β-unfunctionalized ketones proceeds via a DKR (dynamic kinetic resolution) process for the construction of various chiral N,N-disubstituted α-amino β-unfunctionalized alcohols in quantitative yields with excellent enantioselectivities and diastereoselectivities (all products >99% ee and >99:1 dr, TON up to 100 000). Importantly, this catalytic asymmetric hydrogenation with a DKR process provided a highly efficient and powerful synthetic strategy for the preparation of key chiral intermediates of the preclinical antitumor agent (S,S)-R116010.

N-Bromosuccinimide promoted and base switchable one pot synthesis of α-imido and α-amino ketones from styrenes

An N-Bromosuccinimide (NBS) promoted one pot strategy for the synthesis of α-amino functionalized aryl ketones starting from commercially available styrenes has been developed. NBS participates in multiple tasks, such as bromonium ion formation, oxidation of bromohydrin and providing a nucleophilic nitrogen source. The reaction can easily be switched between α-imido and α-amino ketones by the choice of base. This one pot strategy was successfully applied for the synthesis of psychoactive drug candidates, amfepramone, mephedrone and 4-MEC.

Copper bromide reagent and its preparation method, α--aminobenzene acetone and its process for synthesis of derivatives of

The invention discloses a copper bromide reagent, a preparation method thereof, and a synthesis method of alpha-amido propiophenone and derivative thereof. Copper bromide cheap in industry and 2,6-bi[4-(1,1-dimethyl)-2-oxazoline-2-base] pyridine react to directly obtain high yield of high-purity copper bromide reagent, in addition, the copper bromide reagent and propiophenone containing multiple important functional groups have good reaction activity. Due to the characteristic, high yield of alpha-amido propiophenone and derivative thereof can be obtained in mild conditions, conventional expensive azoic compound materials are not used, the cost is lowered to a large extent, the operation requirement is also lowered, and alpha-amido propiophenone and derivative thereof have good application prospect in industry.