ETHYL 2-[(2-CHLOROACETYL)AMINO]ACETATE

Base Information

• Chemical Name: ETHYL 2-[(2-CHLOROACETYL)AMINO]ACETATE
• CAS No.: 41602-50-0
• Molecular Formula: C6H10 Cl N O3
• Molecular Weight: 179.603
• Hs Code.: 2924297099
• Mol file: 41602-50-0.mol

Synonyms:Glycine,N-(chloroacetyl)-, ethyl ester (7CI,9CI); Ethyl2-[(2-chloroacetyl)amino]acetate; Ethyl N-chloroacetylglycinate;N-Chloroacetylglycine ethyl ester

Chemical Property of ETHYL 2-[(2-CHLOROACETYL)AMINO]ACETATE

Chemical Property:

• Vapor Pressure: 0.00144mmHg at 25°C
• Melting Point: 62-65 °C(lit.)
• Boiling Point: 296.4°Cat760mmHg
• Flash Point: 133.1°C
• PSA: 55.40000
• Density: 1.21g/cm³
• LogP: 0.29540

Purity/Quality:

99%+ ^*data from raw suppliers

N-(Chloroacetyl)glycine ethyl ester ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

Total 1 MSDS from other Authors

Useful:

Technology Process of ETHYL 2-[(2-CHLOROACETYL)AMINO]ACETATE

There total 7 articles about ETHYL 2-[(2-CHLOROACETYL)AMINO]ACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

chloroacetyl bromide (15018-06-1) + GlyOEt*HCl (459-73-4) → N-(chloroacetyl)glycine ethyl ester (41602-50-0)

Guidance literature:

With potassium carbonate; In dichloromethane; water; at -10 - 20 ℃; for 16h;

DOI:10.24820/ARK.5550190.P011.397

Reference yield: 80.0%

glycine ethyl ester hydrochloride (623-33-6) + chloroacetyl chloride (79-04-9) → N-(chloroacetyl)glycine ethyl ester (41602-50-0)

Guidance literature:

With sodium hydrogencarbonate; In water; toluene; at 20 ℃; for 13h; Cooling with ice;

Reference yield: 72.0%

chloroacetyl chloride (79-04-9) + GlyOEt*HCl (459-73-4) → N-(chloroacetyl)glycine ethyl ester (41602-50-0)

Guidance literature:

In ethyl acetate; for 7.5h; Heating;

upstream raw materials:

N-(2-diazoacetyl)glycine ethyl ester

glycine ethyl ester hydrochloride

chloroacetic acid ethyl ester

GlyOEt*HCl

Downstream raw materials:

4-ethoxy-7-oxo-3-oxa-5-thia-8-aza-4-phosphadecan-10-oic acid, ethyl ester, 4-sulfide

[2-(Ethoxy-methyl-phosphinothioylsulfanyl)-acetylamino]-acetic acid ethyl ester

N-(N-Cyclohexyl-glycyl)-glycin-aethylester

2-Acetoxy-benzoic acid (ethoxycarbonylmethyl-carbamoyl)-methyl ester

Refernces

Synthesis of Potential Haptens with Morphine Skeleton and Determination of Protonation Constants

10.3390/molecules25174009

The research focuses on the synthesis of potential haptens based on the morphine skeleton, aimed at developing a vaccination strategy against drug addiction and abuse. Haptens, which require a free amino or carboxylic group for coupling with an immunogenic carrier protein, were synthesized through reactions involving ethyl acrylate, ethyl bromoacetate, and N-(chloroacetyl)glycine ethyl ester. The study detailed the synthesis process, including N-demethylation and N-alkylation, and the subsequent hydrolysis to obtain N-carboxymethyl- and N-carboxyethyl-normorphine derivatives. The acid-base properties of these molecules were characterized using pH-potentiometry and NMR-pH titrations, with the protonation constants being determined to understand their pharmacokinetic behavior. The experiments utilized various reagents, solvents, and analytical techniques such as NMR, HR-MS, and potentiometric titrations to confirm the structures and physiochemical properties of the synthesized compounds.