1H-imidazole-4,5-dicarbohydrazide

Base Information

• Chemical Name: 1H-imidazole-4,5-dicarbohydrazide
• CAS No.: 5423-20-1
• Molecular Formula: C5H8 N6 O2
• Molecular Weight: 184.158
• Hs Code.: 2933290090
• European Community (EC) Number: 226-550-3
• NSC Number: 64855,10005
• UNII: UW0S5PMS3T
• DSSTox Substance ID: DTXSID50202577
• Nikkaji Number: J218.003K
• Wikidata: Q83075879
• Mol file: 5423-20-1.mol

Synonyms:1H-imidazole-4,5-dicarbohydrazide;5423-20-1;1H-Imidazole-4,5-di(carbohydrazide);UW0S5PMS3T;EINECS 226-550-3;NSC 10005;NSC-10005;NSC-64855;NSC10005;UNII-UW0S5PMS3T;NCIOpen2_000300;1H-Imidazole-4,5-dicarboxylic acid, dihydrazide;Oprea1_283753;DTXSID50202577;NSC64855;MFCD00723482;STK392207;AKOS000567247;LS-09104;CS-0327030;SR-01000596903;IMIDAZOLE-4,5-DICARBOXYLIC ACID, DIHYDRAZIDE;SR-01000596903-1

Chemical Property of 1H-imidazole-4,5-dicarbohydrazide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 138.92000
• Density: 1.587g/cm³
• LogP: -0.20090
• XLogP3: -2.2
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 184.07087352
• Heavy Atom Count: 13
• Complexity: 219

Purity/Quality:

99% ^*data from raw suppliers

1H-Imidazole-4,5-dicarbohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=NC(=C(N1)C(=O)NN)C(=O)NN

Technology Process of 1H-imidazole-4,5-dicarbohydrazide

There total 4 articles about 1H-imidazole-4,5-dicarbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

dimethyl imidazole-4,5-dicarboxylate (3304-70-9) → 1H-imidazole-4,5-dicarboxylic acid dihydrazide (5423-20-1)

Guidance literature:

With hydrazine hydrate; In methanol; for 3h; Heating;

DOI:10.1081/SCC-120021831

Reference yield:

imidazole 4,5-dicarboxylic acid diethyl ester (1080-79-1) → 1H-imidazole-4,5-dicarboxylic acid dihydrazide (5423-20-1)

Guidance literature:

With hydrazine hydrate;

DOI:10.1093/jmt/38.3.193

Reference yield:

4,5-imidazoledicarboxylic acid (570-22-9) → 1H-imidazole-4,5-dicarboxylic acid dihydrazide (5423-20-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / 100 percent H₂SO₄

2: 95 percent / 80 percent hydrazine hydrate / methanol / 3 h / Heating

With sulfuric acid; hydrazine hydrate; In methanol;

DOI:10.1081/SCC-120021831

upstream raw materials:

dimethyl imidazole-4,5-dicarboxylate

imidazole 4,5-dicarboxylic acid diethyl ester

4,5-imidazoledicarboxylic acid

Downstream raw materials:

1H-imidazole-4,5-dicarboxylic acid bis-benzylidenehydrazide

7-chloro-1,5-dihydro-imidazo[4,5-d]pyridazin-4-one

5,6-dihydro-1H-imidazo[4,5-d]pyridazine-4,7-dithione

4,7-dichloro-1H-imidazo[4,5-d]pyridazine