4-Hydrazinyl-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carbohydrazide

Base Information

• Chemical Name: 4-Hydrazinyl-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carbohydrazide
• CAS No.: 129109-53-1
• Molecular Formula: C11H12 N6 O2
• Molecular Weight: 260.252
• DSSTox Substance ID: DTXSID90382766
• Wikidata: Q82174183
• Mol file: 129109-53-1.mol

Synonyms:DTXSID90382766;4-Hydrazinyl-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carbohydrazide

Chemical Property of 4-Hydrazinyl-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carbohydrazide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.56g/cm³
• XLogP3: 0
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 260.10217365
• Heavy Atom Count: 19
• Complexity: 439

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)N2C(=O)C=C(C(=N2)C(=O)NN)NN

Technology Process of 4-Hydrazinyl-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carbohydrazide

There total 2 articles about 4-Hydrazinyl-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

methyl 5-chloro-3-oxo-2-phenyl-2,3-dihydropyridazine-6-carboxylate (129109-17-7) → 5-Hydrazino-3-oxo-2-phenyl-2,3-dihydropyridazine-6-carboxylic hydrazide (129109-53-1)

Guidance literature:

With hydrazine hydrate; In ethanol; for 0.25h; Heating;

Reference yield:

methyl 2-phenyl-5-hydroxy-3-oxo-2,3-dihydropyridazine-6-carboxylate (121582-53-4) → 5-Hydrazino-3-oxo-2-phenyl-2,3-dihydropyridazine-6-carboxylic hydrazide (129109-53-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / POCl₃ / 3 h / 95 - 100 °C

2: 84 percent / N₂H₄*H₂O / ethanol / 0.25 h / Heating

With hydrazine hydrate; trichlorophosphate; In ethanol;

Reference yield: 100.0%

5-Hydrazino-3-oxo-2-phenyl-2,3-dihydropyridazine-6-carboxylic hydrazide (129109-53-1) + benzaldehyde (100-52-7) → 6-Oxo-1-phenyl-4-{N'-[1-phenyl-meth-(Z)-ylidene]-hydrazino}-1,6-dihydro-pyridazine-3-carboxylic acid [1-phenyl-meth-(E)-ylidene]-hydrazide (129109-39-3)

Guidance literature:

In ethanol; for 0.166667h; Heating;

upstream raw materials:

methyl 5-chloro-3-oxo-2-phenyl-2,3-dihydropyridazine-6-carboxylate

methyl 2-phenyl-5-hydroxy-3-oxo-2,3-dihydropyridazine-6-carboxylate

Downstream raw materials:

6-Oxo-1-phenyl-4-{N'-[1-phenyl-meth-(Z)-ylidene]-hydrazino}-1,6-dihydro-pyridazine-3-carboxylic acid [1-phenyl-meth-(E)-ylidene]-hydrazide

4-{N'-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-hydrazino}-6-oxo-1-phenyl-1,6-dihydro-pyridazine-3-carboxylic acid [1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide

4-{N'-[1-(4-Hydroxy-3-methoxy-phenyl)-meth-(Z)-ylidene]-hydrazino}-6-oxo-1-phenyl-1,6-dihydro-pyridazine-3-carboxylic acid [1-(4-hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide

5-Ethylidenehydrazino-6-ethylidenehydrazinocarbonyl-2-phenylpyridazine-3(2H)-one