2-benzyl-1-methylpiperidine

Base Information

• Chemical Name: 2-benzyl-1-methylpiperidine
• CAS No.: 31414-56-9
• Molecular Formula: C13H19 N
• Molecular Weight: 189.2967
• Mol file: 31414-56-9.mol

Synonyms:Piperidine,2-benzyl-1-methyl- (6CI,8CI); 1-Methyl-2-benzylpiperidine; NSC 363741

Chemical Property of 2-benzyl-1-methylpiperidine

Chemical Property:

• Vapor Pressure: 0.00844mmHg at 25°C
• Boiling Point: 266.8°Cat760mmHg
• Flash Point: 105.3°C
• Density: 0.966g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-benzyl-1-methylpiperidine

There total 11 articles about 2-benzyl-1-methylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

C13H19N → N-Methyl-2-(phenylmethyl)piperidine (31414-56-9)

Guidance literature:

With phosphazene base-P₄-tert-butyl; In tetrahydrofuran; hexane; for 144h; Reflux;

DOI:10.1016/j.tetlet.2021.153599

Reference yield:

methanol (67-56-1) → N-Methyl-2-(phenylmethyl)piperidine (31414-56-9)

Guidance literature:

With copper oxide-chromium oxide; hydrogen; at 180 - 200 ℃; under 91938.4 Torr;

DOI:10.1016/S0196-8904(01)00184-4

Reference yield:

6-benzyl-1-methyl-1,2,3,4-tetrahydro-pyridine (107202-92-6) → N-Methyl-2-(phenylmethyl)piperidine (31414-56-9)

Guidance literature:

With ethanol; platinum; Hydrogenation;

DOI:10.1021/jo01170a021

upstream raw materials:

6-benzyl-1-methyl-1,2,3,4-tetrahydro-pyridine

2-benzylpiperidine

methyl iodide

1-benzyl-1-methyl-piperidinium; iodide

Downstream raw materials:

C₁₃H₁₈N⁽¹⁺⁾*ClO₄^(1-)

Refernces

• 1、 Gawley, Robert E.,Zhang, Qianhui. "Alkylation of 2-Lithio-N-Methylpiperidines and -pyrrolidines: Scope, Limitations, and Stereochemistry". . p. 5763 - 5769. Retrieved 2007/10/03.
• 2、 Lewis, Frederick D.,Reddy, G. Dasharatha. "Intramolecular Photochemical Addition Reactions of ω-Styrylaminoalkanes". . p. 6465 - 6466. Retrieved 2007/10/02.