Nelfinavir

Base Information

Chemical Name:Nelfinavir
CAS No.:159989-64-7
Molecular Formula:C32H45N3O4S
Molecular Weight:567.793
Hs Code.:
NSC Number:747167
UNII:HO3OGH5D7I
DSSTox Substance ID:DTXSID5035080
Nikkaji Number:J1.642.472B
Wikipedia:Nelfinavir
Wikidata:Q423366
NCI Thesaurus Code:C29285
RXCUI:134527
Pharos Ligand ID:W5WX2J7S1R92
Metabolomics Workbench ID:42622
ChEMBL ID:CHEMBL584
Mol file:159989-64-7.mol

Synonyms:AG 1343;AG-1343;AG1343;Mesylate, Nelfinavir;Monomethane Sulfonate, Nelfinavir;Nelfinavir;Nelfinavir Mesylate;Nelfinavir Monomethane Sulfonate;Sulfonate, Nelfinavir Monomethane;Viracept

Suppliers and Price of Nelfinavir

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
Nelfinavir-d4
1 mg
$ 715.00

DC Chemicals
Nelfinavir >98%
250 mg
$ 950.00

DC Chemicals
Nelfinavir >98%
100 mg
$ 550.00

CSNpharm
Nelfinavir
50mg
$ 238.00

Crysdot
Nelfinavir 98+%
50mg
$ 450.00

Crysdot
Nelfinavir 98+%
10mg
$ 240.00

ChemScene
Nelfinavir 96.90%
5mg
$ 100.00

ChemScene
Nelfinavir 96.90%
50mg
$ 280.00

ChemScene
Nelfinavir 96.90%
10mg
$ 140.00

Chemenu
(3S,4aS,8aS)-N-(tert-butyl)-2-((2R,3R)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)-4-(phenylthio)butyl)decahydroisoquinoline-3-carboxamide 98%
50mg
$ 720.00

Total 83 raw suppliers

Chemical Property of Nelfinavir

Chemical Property:

Appearance/Colour:white to off-white crystalline powder
Vapor Pressure:4.38E-26mmHg at 25°C
Melting Point:185-186 °C
Refractive Index:1.618
Boiling Point:786.839 °C at 760 mmHg
PKA:pKa1 6.0; pKa2 11.06(at 25℃)
Flash Point:429.665 °C
PSA：189.95000
Density:1.226 g/cm³
LogP:6.05210
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
Water Solubility.:7g/L(temperature not stated)
XLogP3:5.7
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:10
Exact Mass:567.31307810
Heavy Atom Count:40
Complexity:830

Purity/Quality:

99%, ^*data from raw suppliers

Nelfinavir-d4 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Drug Classes:Antiviral Agents
Canonical SMILES:CC1=C(C=CC=C1O)C(=O)NC(CSC2=CC=CC=C2)C(CN3CC4CCCCC4CC3C(=O)NC(C)(C)C)O
Isomeric SMILES:CC1=C(C=CC=C1O)C(=O)N[C@@H](CSC2=CC=CC=C2)[C@@H](CN3C[C@H]4CCCC[C@H]4C[C@H]3C(=O)NC(C)(C)C)O
Recent ClinicalTrials:Nelfinavir and Lenalidomide/Dexamethasone in Progressive Multiple Myeloma
Recent EU Clinical Trials:A multi-centre randomised study of induction chemotherapy followed by capecitabine (+/-nelfinavir) with high or standard dose radiotherapy for locally advanced non-metastatic pancreatic cancer
Recent NIPH Clinical Trials:Evaluation of Nelfinavir for asymptomatic and mild COVID-19
Uses Antiviral.
Indications Nelfinavir (Viracept) is probably the most commonly used protease inhibitor because of its low incidence of serious adverse effects. Its most common side effects are diarrhea and flatulence; these may resolve with continued use. In addition to the drugs contraindicated for use with all protease inhibitors, amiodarone, rifampin, and quinidine are contraindicated in patients taking nelfinavir.
Clinical Use Treatment of HIV infection (in combination with other antiretroviral drugs)

Technology Process of Nelfinavir

There total 29 articles about Nelfinavir which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 108-98-5
thiophenol

: 188936-07-4
(3S,4aS,8aS)-N-tert-butyl-2-((R)-2-hydroxy-2-((S)-2-(3-hydroxy-2-methylphenyl)-4,5-dihydrooxazol-4-yl)ethyl)-decahydroisoquinoline-3-carboxamide

: 159989-64-7
nelfinavir

Guidance literature:: DOI:10.1016/S0040-4039(01)01338-7

Reference yield: 79.0%

: 167678-46-8
3-acetoxy-2-methylbenzoyl chloride

: 201402-98-4
(2R,3R)-4-((3S,4aS,8aS)-3-(tertbutylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-3-hydroxy-1-(phenylthio)butan-2-aminium benzoate

: 159989-64-7
nelfinavir

Guidance literature:: 3-acetoxy-2-methylbenzoyl chloride; (2R,3R)-4-((3S,4aS,8aS)-3-(tertbutylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-3-hydroxy-1-(phenylthio)butan-2-aminium benzoate; In ethanol;

With sodium hydroxide;
DOI:10.1016/S0040-4039(01)01338-7