2,4,6-Trimethoxybenzophenone

Base Information

• Chemical Name: 2,4,6-Trimethoxybenzophenone
• CAS No.: 3770-80-7
• Molecular Formula: C16H16 O4
• Molecular Weight: 272.301
• Hs Code.: 2914509090
• European Community (EC) Number: 223-209-0
• UNII: 789MD6GU47
• DSSTox Substance ID: DTXSID8063179
• Nikkaji Number: J217.669F
• Wikidata: Q27266657
• Metabolomics Workbench ID: 46214
• Mol file: 3770-80-7.mol

Synonyms:2,4,6-Trimethoxybenzophenone;3770-80-7;Methylhydrocotoin;Phenyl(2,4,6-trimethoxyphenyl)methanone;phenyl-(2,4,6-trimethoxyphenyl)methanone;Methanone, phenyl(2,4,6-trimethoxyphenyl)-;EINECS 223-209-0;UNII-789MD6GU47;789MD6GU47;SCHEMBL2288468;DTXSID8063179;CHEBI:174583;AKOS024332998;BENZOPHENONE, 2,4,6-TRIMETHOXY-;Phenyl(2,4,6-trimethoxyphenyl)-Methanone;FT-0715720;Q27266657

Chemical Property of 2,4,6-Trimethoxybenzophenone

Chemical Property:

• Vapor Pressure: 4.43E-08mmHg at 25°C
• Melting Point: 113–115°C
• Boiling Point: 444°Cat760mmHg
• Flash Point: 197.9°C
• PSA: 44.76000
• Density: 1.136g/cm³
• LogP: 2.94340
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 272.10485899
• Heavy Atom Count: 20
• Complexity: 298

Purity/Quality:

98%Min ^*data from raw suppliers

2,4,6-TRIMETHOXYBENZOPHENONE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC(=C(C(=C1)OC)C(=O)C2=CC=CC=C2)OC

Technology Process of 2,4,6-Trimethoxybenzophenone

There total 25 articles about 2,4,6-Trimethoxybenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1,2,3-trimethoxybenzene (621-23-8) + Te-methyl benzotelluroate (76399-11-6) → 2,4,6-trimethoxybenzophenone (3770-80-7)

Guidance literature:

With silver trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1246/cl.2008.650

Reference yield: 88.0%

1,2,3-trimethoxybenzene (621-23-8) + phenyl selenobenzoate (38447-68-6) → 2,4,6-trimethoxybenzophenone (3770-80-7)

Guidance literature:

With 9,10-dimethoxyanthracene; In acetonitrile; at 20 ℃; Inert atmosphere; Irradiation;

DOI:10.1039/c7cc07529d

Reference yield: 82.0%

1,2,3-trimethoxybenzene (621-23-8) + benzoic acid anhydride (93-97-0) → 2,4,6-trimethoxybenzophenone (3770-80-7)

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 1.5h;

DOI:10.1016/j.tetlet.2018.01.026

upstream raw materials:

diazomethane

diethyl ether

2-benzoylphloroglucinol

1,2,3-trimethoxybenzene

Downstream raw materials:

Benzoyl bromide

2,4,6-tribromophloroglucinol

2,6-dihydroxy-4-prenyloxybenzophenone

phenyl(2,4,6-trihydroxy-3,5-bis(3-methylbut-2-en-1-yl)-phenyl)methanone

Refernces

• 1、 Zhao, Weining,Cross, Ashley R.,Crowe-McAuliffe, Caillan,Weigert-Munoz, Angela,Csatary, Erika E.,Solinski, Amy E.,Krysiak, Joanna,Goldberg, Joanna B.,Wilson, Daniel N.,Medina, Eva,Wuest, William M.,Sieber, Stephan A.. "The Natural Product Elegaphenone Potentiates Antibiotic Effects against Pseudomonas aeruginosa". supporting information. p. 8581 - 8584. Retrieved 2019/05/28.
• 2、 Pandey, Ganesh,Tiwari, Sandip Kumar,Singh, Bhawana,Vanka, Kumar,Jain, Shailja. "P -Selective (sp2)-C-H functionalization for an acylation/alkylation reaction using organic photoredox catalysis". supporting information. p. 12337 - 12340. Retrieved 2017/11/20.