6-Methyl-2-phenylquinoline

Base Information

• Chemical Name: 6-Methyl-2-phenylquinoline
• CAS No.: 27356-46-3
• Molecular Formula: C16H13 N
• Molecular Weight: 219.286
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID60181788
• Nikkaji Number: J122.314C
• Wikidata: Q72497908
• Metabolomics Workbench ID: 135881
• ChEMBL ID: CHEMBL459923
• Mol file: 27356-46-3.mol

Synonyms:6-METHYL-2-PHENYLQUINOLINE;27356-46-3;Quinoline, 6-methyl-2-phenyl-;6-Methyl-2-phenyl-quinoline;SOLVENTBLUE36;2-phenyl-6-methyl-quinoline;6-Methyl-2-phenylquinoline #;CHEMBL459923;SCHEMBL8830006;DTXSID60181788;AKOS016002921;AC-9586;SB70542;FT-0761802;A26314;AN-829/42535952

Chemical Property of 6-Methyl-2-phenylquinoline

Chemical Property:

• Vapor Pressure: 1.33E-05mmHg at 25°C
• Boiling Point: 378.9°Cat760mmHg
• Flash Point: 165.7°C
• PSA: 12.89000
• Density: 1.105g/cm³
• LogP: 4.21020
• XLogP3: 4.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 219.104799419
• Heavy Atom Count: 17
• Complexity: 244

Purity/Quality:

97% ^*data from raw suppliers

6-Methyl-2-phenylquinoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC2=C(C=C1)N=C(C=C2)C3=CC=CC=C3

Technology Process of 6-Methyl-2-phenylquinoline

There total 56 articles about 6-Methyl-2-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-amino-5-methylbenzyl alcohol (34897-84-2) + acetophenone (98-86-2) → 6-methyl-2-phenyl-quinoline (27356-46-3)

Guidance literature:

With potassium hydroxide; 1,3-diisopropyl-1H-benzo[d]imidazol-3-ium bromide; In toluene; at 60 ℃; for 1h;

DOI:10.1039/c4ra07858f

Reference yield: 95.0%

(E)-3-(2-amino-5-methylphenyl)acrylonitrile (1449337-38-5) + phenylboronic acid (98-80-6) → 6-methyl-2-phenyl-quinoline (27356-46-3)

Guidance literature:

With palladium(II) trifluoroacetate; toluene-4-sulfonic acid; at 90 ℃; for 36h;

Reference yield: 92.0%

2-amino-5-methylbenzyl alcohol (34897-84-2) + 1-Phenylethanol (98-85-1,13323-81-4) → 6-methyl-2-phenyl-quinoline (27356-46-3)

Guidance literature:

With C₂₂H₂₄ClIrN₃O⁽¹⁺⁾*Cl^(1-); potassium hydroxide; In water; at 120 ℃; for 24h; Green chemistry;

DOI:10.1016/j.jcat.2019.03.028

upstream raw materials:

6-methylquinoline-N-oxide

benzaldehyde

p-toluidine

acetylene

Downstream raw materials:

2-phenyl-quinoline-6-carboxylic acid

7-methyl-2,4,4-triphenyl-1,2,4,5-tetrahydro-2,5-methano-benzo[d][1,3]oxazepine

2-phenyl-6-bromomethyl-quinoline

6-methyl-2-phenylquinoline 1-oxide