1,1-Dimethoxypropan-2-amine

Base Information

• Chemical Name: 1,1-Dimethoxypropan-2-amine
• CAS No.: 57390-38-2
• Molecular Formula: C5H13 N O2
• Molecular Weight: 119.164
• European Community (EC) Number: 260-717-1
• DSSTox Substance ID: DTXSID50972884
• Nikkaji Number: J349.148J
• Mol file: 57390-38-2.mol

Synonyms:1,1-dimethoxypropan-2-amine;57390-38-2;2,2-Dimethoxy-1-methylethylamine;1,1-Dimethoxy-2-propanamine;2-aminopropionaldehyde dimethyl acetal;2-Propanamine, 1,1-dimethoxy-;EINECS 260-717-1;SCHEMBL924549;DTXSID50972884;aminopropionaldehyde dimethyl acetal;2-aminopropionaldehyde dimethylacetal;MFCD00082189;AKOS009156875;alpha-aminopropionaldehyde dimethyl acetal;BS-12941;EN300-67364;Z1079182758

Chemical Property of 1,1-Dimethoxypropan-2-amine

Chemical Property:

• Vapor Pressure: 4.06mmHg at 25°C
• Boiling Point: 149.3°Cat760mmHg
• PKA: 7.00±0.10(Predicted)
• Flash Point: 44.1°C
• PSA: 44.48000
• Density: 0.929g/cm³
• LogP: 0.65280
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 119.094628657
• Heavy Atom Count: 8
• Complexity: 54.4

Purity/Quality:

99% ^*data from raw suppliers

1,1-Dimethoxy-2-propanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(OC)OC)N
• Uses: 1,1-Dimethoxy-2-propanamine, can be used for the synthesis of N-protected α-amino aldehydes occur as C-terminal units of peptide aldehydes with enzyme inhibitor activity, such as Leupeptin. They can also be used for the preparation of amino sugars, and unusual amino acids.

Technology Process of 1,1-Dimethoxypropan-2-amine

There total 8 articles about 1,1-Dimethoxypropan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

Pyruvic aldehyde dimethyl acetal (6342-56-9) → 2-amino-propionaldehyde dimethyl acetal (57390-38-2)

Guidance literature:

With ammonia; In methanol;

Reference yield: 69.0%

C22H25NO3 (1195046-02-6) → 1-benzyl-2-naphthol (36441-31-3) + 2-amino-propionaldehyde dimethyl acetal (57390-38-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 12h; under 760.051 Torr;

DOI:10.1055/s-0029-1216943

Reference yield: 52.0%

2-azidopropanal dimethyl acetal (59566-61-9) → 2-amino-propionaldehyde dimethyl acetal (57390-38-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; under 2585.7 Torr; Ambient temperature;

DOI:10.1021/jo00321a010

upstream raw materials:

2-azidopropanal dimethyl acetal

2-bromo-1,1-dimethoxypropane

Pyruvic aldehyde dimethyl acetal

C₂₂H₂₅NO₃

Downstream raw materials:

4-bromo-2-((2, 2-dimethoxyethyl)(methyl)amino) benzaldehyde

N-[1,1,1-trifluoro-3-(4-nitrophenyl)propan-2-ylidene]-1,1-dimethoxypropan-2-amine

(Z)-3,3,3-trifluoro-N-(1,1-dimethoxypropan-2-yl)-1-(4-nitrophenyl)prop-1-en-2-amine

N-{3-(4-chlorophenyl)-1-[(1,1-dimethoxyethyl)amino]-3-[(2,2-dimethoxy-1-methylethyl)amino]prop-2-enylidene}-1,1-dimethoxypropan-2-aminium bromide

Refernces

• 1、 -. "1,4-DISUBSTITUTED PYRIDAZINE DERIVATIVES AND THEIR USE FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS". . . Retrieved 2015/02/25.
• 2、 -. "1,2,4 -TRIAZOLES AS ALLOSTERIC MODULATORS OF MGLU5 RECEPTOR ACTIVITY FOR THE TREATMENT OF SCHIZOPHRENIA OF DEMENTIA". . . Retrieved 2013/06/27.