2-Chloro-1,1-difluoro-1-methoxyethane

Base Information

• Chemical Name: 2-Chloro-1,1-difluoro-1-methoxyethane
• CAS No.: 428-65-9
• Molecular Formula: C3H5ClF2O
• Molecular Weight: 130.521
• DSSTox Substance ID: DTXSID80195488
• Nikkaji Number: J42.990B
• Wikidata: Q83068441
• Mol file: 428-65-9.mol

Synonyms:2-Chloro-1,1-difluoro-1-methoxyethane;428-65-9;BRN 1734832;ETHANE, 2-CHLORO-1,1-DIFLUORO-1-METHOXY-;C3H5ClF2O;C3-H5-Cl-F2-O;DTXSID80195488;AKOS006384463;LS-65237

Chemical Property of 2-Chloro-1,1-difluoro-1-methoxyethane

Chemical Property:

• Vapor Pressure: 229mmHg at 25°C
• Boiling Point: 57.7°Cat760mmHg
• Flash Point: °C
• PSA: 9.23000
• Density: 1.222g/cm³
• LogP: 1.46440
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 129.9996988
• Heavy Atom Count: 7
• Complexity: 56.9

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(CCl)(F)F

Technology Process of 2-Chloro-1,1-difluoro-1-methoxyethane

There total 4 articles about 2-Chloro-1,1-difluoro-1-methoxyethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methyl chloroacetate (96-34-4) → 2,2-difluoro-1-chloro-3-oxabutane (428-65-9)

Guidance literature:

With chlorine monofluoride; In hydrogen fluoride; at -60 - -40 ℃; for 0.3h;

Reference yield:

methanol (67-56-1) + 1-Chloro-2,2-difluoroethene (359-10-4) → 2,2-difluoro-1-chloro-3-oxabutane (428-65-9)

Guidance literature:

With potassium hydroxide;

DOI:10.1021/ja01148a104

Reference yield:

1-Chloro-2,2-difluoroethene (359-10-4) → 2,2-difluoro-1-chloro-3-oxabutane (428-65-9)

Guidance literature:

at 57 ℃;

DOI:10.1021/ja01148a104

upstream raw materials:

methanol

1-Chloro-2,2-difluoroethene

methyl chloroacetate