methyl 2-cyclopropylacetate

Base Information

• Chemical Name: methyl 2-cyclopropylacetate
• CAS No.: 34108-21-9
• Molecular Formula: C6H10 O2
• Molecular Weight: 114.14
• Hs Code.: 2916200090
• Mol file: 34108-21-9.mol

Synonyms:Cyclopropylaceticacid methyl ester; Methyl 2-cyclopropylacetate; Methyl cyclopropaneacetate;Methyl cyclopropylacetate; NSC 250978

Chemical Property of methyl 2-cyclopropylacetate

Chemical Property:

• Vapor Pressure: 6.85mmHg at 25°C
• Boiling Point: 138.1°Cat760mmHg
• Flash Point: 29.4°C
• PSA: 26.30000
• Density: 1.03g/cm³
• LogP: 0.95950
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-Cyclopropylacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 2-Cyclopropylacetate is used in preparation of Heterocyclyldihydropyrazolopyrimidinone derivatives for use as PDE9A modulators.

Technology Process of methyl 2-cyclopropylacetate

There total 9 articles about methyl 2-cyclopropylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

cyclopropylacetic acid (5239-82-7) → methyl cyclopropylacetate (34108-21-9)

Guidance literature:

With sulfuric acid; In methanol;

Reference yield: 75.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + but-3-enoic acid (625-38-7) → methyl cyclopropylacetate (34108-21-9)

Guidance literature:

With palladium diacetate; In diethyl ether; at 0 ℃; for 0.166667h;

DOI:10.1080/00397919208019279

Reference yield: 45.0%

methanol (67-56-1) + cyclopropylacetic acid (5239-82-7) → methyl cyclopropylacetate (34108-21-9)

Guidance literature:

With sulfuric acid; for 16h; Reflux;

DOI:10.1016/j.bmc.2015.02.019

upstream raw materials:

diazomethane

diiodomethane

but-3-enoic acid

cyclopropylacetic acid

Downstream raw materials:

1,1-Diphenyl-2-cyclopropyl-aethanol

1-cyclopropylethanol

methyl 2-cylopropyl-3-hydroxy-3-phenylpropanoate

5-cyclopropyl-2-thio-2,3-dihydropyrimidine-2,4(1H,3H)-dione