N(4)-desoxychlordiazepoxide

Base Information

• Chemical Name: N(4)-desoxychlordiazepoxide
• CAS No.: 4393-72-0
• Molecular Formula: C16H14ClN3
• Molecular Weight: 283.76
• Hs Code.: 2933990090
• Mol file: 4393-72-0.mol

Synonyms:RCDZ;7-Chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine;2-Methylamino-5-phenyl-7-chlor-3H-1,4-benzodiazepin;Chlordiazepoxid;3H-1,4-Benzodiazepin-2-amine,7-chloro-N-methyl-5-phenyl;Chlordiazepam;7-Chlor-2-methylamino-5-phenyl-3H-1,4-benzodiazepin;Chlorodiazepoxide;

Chemical Property of N(4)-desoxychlordiazepoxide

Chemical Property:

• Vapor Pressure: 4.75E-09mmHg at 25°C
• Boiling Point: 471.2°Cat760mmHg
• Flash Point: 238.8°C
• PSA: 36.75000
• Density: 1.24g/cm³
• LogP: 3.20480

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N(4)-desoxychlordiazepoxide

There total 3 articles about N(4)-desoxychlordiazepoxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

desmethyldiazepam (1088-11-5) → (7-chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-ylidene)-methyl-amine (4393-72-0)

Guidance literature:

Multi-step reaction with 2 steps

1: P₂S₅; NaHCO₃ / acetonitrile / 24 h / Heating

2: acetonitrile; H₂O / 3 h / 20 °C

With tetraphosphorus decasulfide; sodium hydrogencarbonate; In water; acetonitrile;

DOI:10.1055/s-2004-831243

Reference yield:

methylamine (74-89-5) + 7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-thione (4547-02-8) → (7-chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-ylidene)-methyl-amine (4393-72-0)

Guidance literature:

In water; acetonitrile; at 20 ℃; for 3h;

DOI:10.1055/s-2004-831243

Reference yield:

→ 2-(methylamino)-5-phenyl-7-chloro-3H-1,4-benzodiazepine (4393-72-0)

Guidance literature:

7-Chlor-2-methylamino-5-phenyl-3H-1,4-benzodiazepin-4-oxyd, H2, Pd-C, A.;

DOI:10.1021/jm01236a008

upstream raw materials:

methylamine

7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-thione

desmethyldiazepam

Downstream raw materials:

8?chloro?6?phenyl?3?(4?toluenesulfonyl)?4H?imidazo[1,5?a][1,4]benzodiazepine

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