2,2'-BIBENZOTHIAZOLE

Base Information

• Chemical Name: 2,2'-BIBENZOTHIAZOLE
• CAS No.: 4271-09-4
• Molecular Formula: C14H8N2S2
• Molecular Weight: 268.363
• Hs Code.: 2934999090
• Mol file: 4271-09-4.mol

Synonyms:5004P;2,2'-dibenzothiazolyl;2,2'-dibenzothiazole;2,2'-Bibenzothiazole;2,2'-bisbenzothiazole;

Chemical Property of 2,2'-BIBENZOTHIAZOLE

Chemical Property:

• Melting Point: 300.5 °C
• Boiling Point: 453.8°Cat760mmHg
• PKA: -0.21±0.10(Predicted)
• Flash Point: 220.9°C
• PSA: 82.26000
• Density: 1.424g/cm³
• LogP: 4.57300

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 2,2'-BIBENZOTHIAZOLE

There total 27 articles about 2,2'-BIBENZOTHIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1,3-Benzothiazole (95-16-9) + 2-phenyl-1,3,4-oxadiazole (825-56-9) → 2,2'-benzothiazolyl (4271-09-4) + 2-(benzo[d]thiazol-2-yl)-5-phenyl-1,3,4-oxadiazole (55439-45-7)

Guidance literature:

With pyridine; oxygen; copper diacetate; silver carbonate; In 5,5-dimethyl-1,3-cyclohexadiene; at 140 ℃; for 24h; chemoselective reaction;

DOI:10.1021/jo301128y

Reference yield: 76.0%

1,3-Benzothiazole (95-16-9) + 5-phenyloxazole (1006-68-4) → 2,2'-benzothiazolyl (4271-09-4) + 2-(benzothiazol-2-yl)-5-phenyloxazole (1388625-38-4) + 5,5'-diphenyl-2,2'-bi-1,3-oxazole (17064-30-1)

Guidance literature:

With pyridine; oxygen; copper diacetate; silver carbonate; In 5,5-dimethyl-1,3-cyclohexadiene; at 140 ℃; for 24h; Reagent/catalyst; Solvent; chemoselective reaction;

DOI:10.1021/jo301128y

Reference yield: 75.0%

1,3-Benzothiazole (95-16-9) + 4-(oxazol-5-yl)benzonitrile (87150-13-8) → 2,2'-benzothiazolyl (4271-09-4) + 2-(5-(4-cyanophenyl)oxazol-2-yl)benzothiazole (1395680-17-7)

Guidance literature:

With pyridine; oxygen; copper diacetate; silver carbonate; In 5,5-dimethyl-1,3-cyclohexadiene; at 140 ℃; for 24h; chemoselective reaction;

DOI:10.1021/jo301128y

upstream raw materials:

2-Methylbenzothiazole

aniline

2-chlorobenzo[d][1,3]thiazole

2-(methylsulfinyl)benzothiazole

Downstream raw materials:

S-benzotrizol-2-yl-4-[(4-methylpiperazin-1-yl)methyl]benzoate

imatinib

oxalic acid

2-amino-benzenethiol

Refernces

• 1、 Fan, Shilu,Zhang, Xingang,Chen, Zhao. "Copper-catalyzed dehydrogenative cross-coupling of benzothiazoles with thiazoles and polyfluoroarene". supporting information. p. 4950 - 4953,4. Retrieved 2020/09/16.
• 2、 Ramazanova,Tarakanova,Vagabov,Litvinova,Anisimov. "Reactions of 2-allylthiobenzimidazole, -oxazole, -thiazole, and the isomeric thiones with dichlorocarbene". . p. 201 - 206. Retrieved 2007/10/03.