3-methylcytidine

Base Information

• Chemical Name: 3-methylcytidine
• CAS No.: 2140-64-9
• Molecular Formula: C10H15 N3 O5
• Molecular Weight: 257.246
• Mol file: 2140-64-9.mol

Synonyms:3-Methylcytidine;N3-Methylcytidine

Chemical Property of 3-methylcytidine

Chemical Property:

• Vapor Pressure: 6.88E-11mmHg at 25°C
• Boiling Point: 471.9°Cat760mmHg
• PKA: 13.35±0.70(Predicted)
• Flash Point: 239.2°C
• PSA: 120.70000
• Density: 1.71g/cm³
• LogP: -2.62250

Purity/Quality:

97% ^*data from raw suppliers

N3-Methylcytidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-methylcytidine

There total 3 articles about 3-methylcytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

trimethylsulphonium hydroxide (17287-03-5) + CYTIDINE (65-46-3) → 3'-O-Methylcytidine (20594-00-7) + 2'-O-methylcytidine (2140-72-9,58970-16-4) + N3-methylcytidine (2140-64-9)

Guidance literature:

With copper acetylacetonate; In N,N-dimethyl-formamide; at 70 ℃; for 1h;

DOI:10.1021/jo01307a026

Reference yield: 5.0%

1-methyl-1-nitrosourea (684-93-5) + CYTIDINE (65-46-3) → 2'-O-methylcytidine (2140-72-9,58970-16-4) + N3-methylcytidine (2140-64-9)

Guidance literature:

With borax; In water; formamide; at 50 ℃; for 18h;

DOI:10.1002/anie.201801919

Reference yield:

tert-butyl peroxyacetate (107-71-1) + CYTIDINE (65-46-3) → 4-methylamino-1-(β-D-ribofuranosyl)pyrimidin-2(1H)-one (10578-79-7) + N3-methylcytidine (2140-64-9) + 5-methylcytidine (2140-61-6)

Guidance literature:

at 32 ℃; for 20h; Product distribution; Mechanism; Irradiation; solutions of pH 1.4 - 12.4;

DOI:10.1021/jo01300a022

upstream raw materials:

tert-butyl peroxyacetate

CYTIDINE

trimethylsulphonium hydroxide

1-methyl-1-nitrosourea

Refernces

• 1、 Zady, Mona F.,Wong, John L.. "Unusual Competition between Nitrogen and Carbon Methylation of Nucleosides by Methyl Radical in Various Aqueous Media". . p. 2373 - 2377. Retrieved 2007/10/02.
• 2、 Yamauchi, Kiyoshi,Nakagima, Toru,Kinoshita, Masayoshi. "Methylation study of ribonucleosides, deoxyribonucleosides, and 2′-O-methylribonucleosides with trimethylsulphonium hydroxide and trimethylsulphonium iodide. Influence of the 2′-hydroxy-groups on the reactivity of the base moieties of ribonucleosides". . p. 2787 - 2792. Retrieved 2007/10/02.