1-(Ethoxycarbonyl)-β-carboline

Base Information

• Chemical Name: 1-(Ethoxycarbonyl)-β-carboline
• CAS No.: 72755-19-2
• Molecular Formula: C₁₄H₁₂N₂O₂
• Molecular Weight: 240.261
• Mol file: 72755-19-2.mol

Synonyms:Ethyl β-carboline-4-carboxylate;kumujian A;ethyl 9H-pyrido[3,4-b]indole-1-carboxylate;ethyl β-carboline-1-carboxylate;1-ethoxycarbonyl-β-carboline;

Chemical Property of 1-(Ethoxycarbonyl)-β-carboline

Chemical Property:

• Melting Point: 145-146 °C
• Boiling Point: 470.9±25.0 °C(Predicted)
• PKA: 14.21±0.40(Predicted)
• PSA: 54.98000
• Density: 1.308±0.06 g/cm3(Predicted)
• LogP: 2.89280

Purity/Quality:

Analysis control,HPLC≥95% ^*data from raw suppliers

1-Ethoxycarbonyl-beta-carboline ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(Ethoxycarbonyl)-β-carboline

There total 13 articles about 1-(Ethoxycarbonyl)-β-carboline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4,9-dihydro-3H-β-carboline-1-carboxylic acid ethyl ester (288839-76-9) → 9H-β-carboline-1-carboxylic acid ethyl ester (72755-19-2)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dimethyl sulfoxide; at 25 ℃; for 3h;

DOI:10.1002/ejoc.201300080

Reference yield: 76.0%

ethanol (64-17-5) + benzofuran-2-yl(9H-pyrido[3,4-b]indol-1-yl)methanone → 9H-β-carboline-1-carboxylic acid ethyl ester (72755-19-2)

Guidance literature:

With dipotassium peroxodisulfate; palladium diacetate; trifluoroacetic acid; at 80 ℃; for 24h;

DOI:10.1039/c5ob01500f

Reference yield: 65.0%

[2-(1H-indol-3-yl)-ethylimino]-acetic acid ethyl ester → 9H-β-carboline-1-carboxylic acid ethyl ester (72755-19-2)

Guidance literature:

With gold(III) chloride; silver trifluoromethanesulfonate; In 1,2-dichloro-ethane; at 80 ℃; for 24h;

DOI:10.1021/jo0524775

upstream raw materials:

indole

ethyl 1,2,4-triazine-3-carboxylate

ethanol

9H-pyrido<3,4-b>indole-1-carboxylic acid

Downstream raw materials:

9H-pyrido[3,4-b]indole-1-carboxamide

4-methoxy-6H-indolo[3,2,1-de][1,5]naphthyridin-6-one

ethyl 9-(3-phenylpropyl)-β-carboline-1-carboxylate

pavettine