(3-BROMOBENZYL)METHYLAMINE

Base Information

• Chemical Name: (3-BROMOBENZYL)METHYLAMINE
• CAS No.: 67344-77-8
• Molecular Formula: C8H10BrN
• Molecular Weight: 200.078
• Hs Code.: 2921490060
• Mol file: 67344-77-8.mol

Synonyms:1-(3-bromophenyl)-N-methylmethanamine;(3-Bromophenyl)-N-methylmethanamine;Benzenemethanamine, 3-bromo-N-methyl-;N-(3-Bromobenzyl)-N-methylamine;

Chemical Property of (3-BROMOBENZYL)METHYLAMINE

Chemical Property:

• Vapor Pressure: 0.0478mmHg at 25°C
• Refractive Index: n20/D 1.5650(lit.)
• Boiling Point: 231-232 oC
• PKA: 9.32±0.10(Predicted)
• Flash Point: 110 oC
• PSA: 12.03000
• Density: 1.461
• LogP: 2.55940
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Sensitive.: Air Sensitive

Purity/Quality:

98%,99%, ^*data from raw suppliers

(3-Bromobenzyl)methylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: (3-Bromobenzyl)methylamine is a useful intermediate used in the preparation of 2,4-diamino-6-(benzylmethylamino)quinazolines with antimalarial and antitumor activities.

Technology Process of (3-BROMOBENZYL)METHYLAMINE

There total 14 articles about (3-BROMOBENZYL)METHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

meta-bromobenzyl bromide (823-78-9) + methylamine (74-89-5) → 1-(3-bromophenyl)-N-methylmethanamine (67344-77-8)

Guidance literature:

In ethanol; for 6h; Heating;

DOI:10.1021/jm00151a006

Reference yield: 83.0%

→ 1-(3-bromophenyl)-N-methylmethanamine (67344-77-8)

Guidance literature:

In methanol; water; at 2 ℃; for 2h;

With sodium tetrahydroborate; water; In methanol; at 0 - 20 ℃;

Reference yield: 81.0%

m-bromobenzoic aldehyde (3132-99-8) + methylamine (74-89-5) → 1-(3-bromophenyl)-N-methylmethanamine (67344-77-8)

Guidance literature:

With sodium tetrahydroborate; In methanol; water; at 0 - 20 ℃; for 3.5h; Product distribution / selectivity;

upstream raw materials:

meta-bromobenzyl bromide

methylamine

m-bromobenzoic aldehyde

methylamine hydrochloride

Downstream raw materials:

2,4-diamino-6-<(m-bromobenzyl)methylamino>pyrido<3,2-d>pyrimidine

3-amino-6-<<(3-bromophenyl)methyl>methylamino>-2-pyridinecarbonitrile

N-nitroso-N-(3-bromobenzyl)methylamine

C₈H₉Br₂N

Refernces

• 1、 -. "FUSED PYRAZOLE DERIVATIVES AS JAK INHIBITORS". Page/Page column 44; 45. . Retrieved 2018/04/11.
• 2、 -. "CRYSTALLINE FORM OF 6-[(4S)-2-METHYL-4-(2-NAPHTHYL)-1,2,3,4-TETRAHYDROISOQUINOLIN-7-YL]PYRIDAZIN-3-AMINE". Paragraph 0072; 0145; 0146. . Retrieved 2014/09/30.